75848-97-4

Upstream product

• 121245-86-1 1-(2-hydroxyphenyl)-3-(3-hydroxyphenyl)prop-2-en-1-one 
• 118-93-4 o-hydroxyacetophenone 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 92496-65-6 3'-Hydroxyflavanone 
• 70460-18-3 3'-hydroxyflavone 
• 73087-51-1 1-(2-hydroxyphenyl)-3-(3-hydroxyphenyl)propan-1-ol 
• 73087-53-3 C₁₅H₁₄O₂ 
• 73087-52-2 3-(2-hydroxyphenyl)indan-4-ol 

Relevant academic research and scientific papers

Intramolecular Alkylation of Phenols. Part 5. A Regiospecific Anionic Ring Closure of Phenols via Quinone Methides

The bis-magnesium salts of the triols (6a) and (6h) cyclise when heated in benzene with high ortho-regiospecificity to the corresponding bis-phenols (7) and (8).The triols (6k) and (6o) under the same conditions cyclise with high para-regiospecificity to the corresponding bis-phenols (7) and (8).Both (6a) and (6h) cyclise via o-quinone methides, and (6k) and (6o) via p-quinone methides.Results from the use of, inter alia, 18-crown-6, indicate that the high ortho-regiospecificity of the cyclisation of (6a) and (6h) is due to intramolecular Mg(II) bridging of the intermediate o-quinone methides.The high para-regiospecificity of cyclisation of (6k) and (6o) is due to steric hindrance towards o-cyclisation of the intermediate p-quinone methides presented by the Mg(II) cation.The unexpected facility with which (6a) and (6k) undergo ring closure is discussed.