75859-35-7Relevant academic research and scientific papers
A silica-supported titanium catalyst for heterogeneous hydroamination and multicomponent coupling reactions
Aldrich, Kelly E.,Odom, Aaron L.
, p. 11352 - 11360 (2019/08/07)
Highly dehydrated silica gel, SiO2700, gave a material with a total surface hydroxyl density of 0.31 ± 0.05 mmol g-1, 0.9 ± 0.1 Si-OH sites per nm2. Treatment of this material with Ti(NMe2)4/sub
A New Phenoxide Chelated IrIII N-Heterocyclic Carbene Complex and Its Application in Reductive Amination Reactions
Gülcemal, Derya,Gülcemal, Süleyman,Robertson, Craig M.,Xiao, Jianliang
, p. 4394 - 4400 (2015/09/22)
A new phenoxide chelated [Ir(NHC)CpCl] (NHC = N-heterocyclic carbene; Cp = pentamethylcyclopentadienyl) complex (3) has been prepared by reaction of [IrCpCl2]2 with an in situ prepared NHC-Ag complex in dichloromethane at ambient temperature. The IrIII complex was stable toward air and moisture and was fully characterized by 1H, 13C NMR, HRMS, and single-crystal X-ray diffraction. The new complex was found to be an active catalyst for transfer hydrogenative reductive amination under aqueous conditions with formate as hydrogen source as well as hydrogenative reductive amination reactions using H2. Various carbonyl compounds such as aliphatic and aromatic ketones and aldehydes were successfully reacted with amines to give new amines. In comparison with transfer hydrogenative reductive amination, the reductive amination with H2 is faster and permits higher molar ratios of the substrate to the catalyst (S/C).
Zirconium complexes stabilized by amine-bridged bis(phenolato) ligands as precatalysts for intermolecular hydroamination reactions
Sun, Qiu,Wang, Yaorong,Yuan, Dan,Yao, Yingming,Shen, Qi
, p. 20352 - 20360 (2015/12/04)
A series of zirconium complexes bearing amine-bridged bis(phenolato) ligands of different steric and electronic properties have been synthesized, and their activities in catalyzing intermolecular hydroamination reactions have been studied and compared. In
Reductive amination of aldehydes and ketones catalyzed by deep eutectic solvent using sodium borohydride as a reducing agent
Saberi, Dariush,Akbari, Jafar,Mahdudi, Samaneh,Heydari, Akbar
, p. 208 - 210 (2014/05/06)
Different derivatives of aldehydes/ketones were subjected under reductive amination reaction in the presence of ChCl/Urea as a green and biocompatible catalyst. Sodium borohydride was used as a reducing agent. Secondary amines were achieved with high selectivities and yields.
Synthesis of group 4 metal complexes stabilized by an amine-bridged bis(phenolato) ligand and their catalytic behavior in intermolecular hydroamination reactions
Sun, Qiu,Wang, Yaorong,Yuan, Dan,Yao, Yingming,Shen, Qi
, p. 994 - 1001 (2014/03/21)
Zirconium and titanium complexes 1 and 2, bearing an amine-bridged bis(phenolato) ligand, have been synthesized and characterized. Although 1 and 2 were inactive in catalyzing intermolecular hydroamination reactions, cationic complexes generated in situ f
Bis(amidate)bis(amido) titanium complex: A regioselective intermolecular alkyne hydroamination catalyst
Yim, Jacky C.-H.,Bexrud, Jason A.,Ayinla, Rashidat O.,Leitch, David C.,Schafer, Laurel L.
, p. 2015 - 2028 (2014/04/03)
An efficient and selective bis(amidate)bis(amido) titanium precatalyst for the anti-Markovnikov hydroamination of alkynes is reported. Hydroamination of terminal and internal alkynes with primary alkylamines, arylamines, and hydrazines is promoted by 5-10 mol % of Ti catalyst. Various functional groups are tolerated including esters, protected alcohols, and imines. The in situ generated complex shows comparable catalytic activity, demonstrating its synthetic versatility for benchtop application. Applications of this catalyst for the synthesis of amino alcohols and a one-pot procedure for indole synthesis are described. A mechanistic proposal that invokes turnover-limiting protonolysis is presented to rationalize the observed regioselectivities.
N-Alkylation of amines through hydrogen borrowing over a heterogeneous Cu catalyst
Santoro, Federica,Psaro, Rinaldo,Ravasio, Nicoletta,Zaccheria, Federica
, p. 2596 - 2600 (2014/01/06)
Substitution of alkylhalides for the synthesis of amines is a relevant target for synthetic chemists. Secondary amines can be obtained in a one pot-one step reaction from secondary and benzylic alcohols and aniline over a heterogeneous copper catalyst. The process does not require any additive, is intrinsically safe and produces no waste.
Intermolecular hydroamination between nonactivated alkenes and aniline catalyzed by lanthanide salts in ionic solvents
Yin, Peng,Loh, Teck-Peng
supporting information; experimental part, p. 3791 - 3793 (2009/12/05)
An efficient methodology for intermolecular hydroamination of unactivated alkenes and anilines catalyzed by lanthanide salts was developed. The Markovnikov products were obtained in moderate to good yields.
Direct reductive amination and selective 1,2-reduction of α,β-unsaturated aldehydes and ketones by NaBH4 using H3PW12O40 as catalyst
Heydari, Akbar,Khaksar, Samad,Akbari, Jafar,Esfandyari, Maryam,Pourayoubi, Mehrdad,Tajbakhsh, Mahmoud
, p. 1135 - 1138 (2007/10/03)
A simple and convenient procedure for direct reductive amination of aldehydes and ketones with sodium borohydride is described. The reaction has been carried out in methanol in the presence of a catalytic amount of H3PW12O40 (0.5 mol %). α,β-Unsaturated aldehydes and ketones can be easily converted into the corresponding allyl alcohols by reaction with H3PW12O40 (0.5 mol %)/NaBH4.
A novel one-pot reductive amination of aldehydes and ketones with lithium perchlorate and zirconium borohydride-piperazine complexes
Heydari, Akbar,Khaksar, Samad,Esfandyari, Maryam,Tajbakhsh, Mahmoud
, p. 3363 - 3366 (2007/10/03)
A novel, one-pot reductive mono-alkylation method of amines (primary and secondary), 1,2-phenylenediamine, O-trimethylsilylhydroxylamine, and N,N-dimethylhydrazine was developed using LiClO4 (5 mol %) as a source for in situ generation of imine
