7586-43-8 Usage
Uses
Used in Pharmaceutical Industry:
Benzy (methyl) guanidine hemisulfate salt is used as a pharmaceutical intermediate for the synthesis of various drugs, contributing to the development of new medications and therapeutic interventions.
Used in Cardiovascular Applications:
Benzy (methyl) guanidine hemisulfate salt is used as a vasodilator for treating medical conditions such as hypertension and heart failure, helping to improve blood flow and reduce the workload on the heart.
Used in Diabetic Nephropathy Treatment:
Benzy (methyl) guanidine hemisulfate salt is used as a potential treatment for diabetic nephropathy, a serious complication of diabetes that affects the kidneys.
Used in Enzyme Inhibition:
Benzy (methyl) guanidine hemisulfate salt is used to inhibit the activity of certain enzymes, which can be beneficial in the treatment of various medical conditions and in the development of new drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 7586-43-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,5,8 and 6 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 7586-43:
(6*7)+(5*5)+(4*8)+(3*6)+(2*4)+(1*3)=128
128 % 10 = 8
So 7586-43-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H13N3/c1-7(12-9(10)11)8-5-3-2-4-6-8/h2-7H,1H3,(H4,10,11,12)
7586-43-8Relevant academic research and scientific papers
Amidination of amines under microwave conditions using recyclable polymer-bound 1H-pyrazole-1-carboxamidine
Solodenko, Wladimir,Broeker, Patrick,Messinger, Josef,Schoen, Uwe,Kirschning, Andreas
, p. 461 - 466 (2007/10/03)
A convenient one-step transformation of primary and secondary amines into the corresponding unprotected guanidines using 4-benzyl-3,5-dimethyl-1H- pyrazole-1-carboxamidine and its polymer-bound variant is described. The scopes and limitations of the method, the microwave-assistance of amidination as well as a recycling protocol are examined. Georg Thieme Verlag Stuttgart.
A new reagent and its polymer-supported variant for the amidination of amines
Dr?ger, Gerald,Solodenko, Wladimir,Messinger, Josef,Sch?n, Uwe,Kirschning, Andreas
, p. 1401 - 1403 (2007/10/03)
New reagents for the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring, a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic solvents. In addition, the polystyrene-bound analogue 2 was prepared which allows amidination of various amines with high purity.
