758650-60-1Relevant academic research and scientific papers
Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma
Liu, Zhenzhen,Li, Hongli,He, Lian,Xiang, Yu,Tian, Chengsen,Li, Can,Tan, Peng,Jing, Ji,Tian, Yanpin,Du, Lupei,Huang, Yun,Han, Leng,Li, Minyong,Zhou, Yubin
, p. 352 - 7,365 (2019)
Glioblastoma (GBM) is among the most common and malignant types of primary brain tumors in adults, with a dismal prognosis. Although alkylating agents such as temozolomide are widely applied as the first-line treatment for GBM, they often cause chemoresis
1,2- two alkone naphthalene compound and its preparation method and application
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Paragraph 0065; 0066; 0067, (2017/02/24)
The invention discloses a 1,2-diketone naphthalene compound which has a general structural formula (I) described in the specification, wherein Ar represents benzene ring, naphthalene ring, quinoline ring or isoquinoline ring, naphthalene diimide ring or coumarin ring; amino acid is directly connected with the Ar; when a substituent group exists on the Ar, R is an electron-withdrawing, electron-donating or neutral group. The invention further discloses a preparation method of the compound and application of the compound to preparation of inflammation-resistant and immunocompetence-resistant drugs. The compound is relatively good in inflammation and immunological competence resistance, is a CRAC (Ca release activated Ca) blocker with a novel structure, and can be used as a lead compound of the inflammation-resistant and immunocompetence-resistant drugs. According to the preparation method, the reaction condition is mild, raw materials are cheap and easily available, and the operation and the post-treatment process are simple.
