758697-05-1Relevant academic research and scientific papers
Carboxylate bioisosteres of pregabalin
Schwarz, Jacob B.,Colbry, Norman L.,Zhu, Zhijian,Nichelson, Brian,Barta, Nancy S.,Lin, Kristin,Hudack, Raymond A.,Gibbons, Sian E.,Galatsis, Paul,DeOrazio, Russell J.,Manning, David D.,Vartanian, Mark G.,Kinsora, Jack J.,Lotarski, Susan M.,Li, Zheng,Dickerson, Melvin R.,El-Kattan, Ayman,Thorpe, Andrew J.,Donevan, Sean D.,Taylor, Charles P.,Wustrow, David J.
, p. 3559 - 3563 (2006)
Several β-amino tetrazole analogs of gabapentin 1 and pregabalin 2 were prepared by one of two convergent, highly efficient routes, and their affinity for the α2-δ protein examined. Two select compounds with potent affinity for α2-δ,
TETRAZOLE AND OXADIAZOLONE SUBSTITUTED β-AMINO ACID DERIVATIVES
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Page 46-47, (2010/02/08)
This invention relates to novel tetrazole and oxadiazalone β-amino acids derivatives of the formula (I, II), wherein G is (III, IV) wherein R1 through R4 are defined as in the specification, pharmaceutical compositions containing the
