75871-38-4Relevant academic research and scientific papers
Lipase-catalyzed amidation of carboxylic acid and amines
Manova, Daniela,Gallier, Florian,Tak-Tak, Lotfi,Yotava, Lyubov,Lubin-Germain, Nadège
supporting information, p. 2086 - 2090 (2018/05/04)
The amidation reaction is of a very particular interest, especially in the pharmaceutical industry and always requires the activation of the acid with a large excess of reactants. Therefore, a large amount of waste is generated. In order to reduce the environmental impact of such reaction, we have developed enzymatic amidation conditions which are compatible with a wide range of amines and acids, in particular with the biologically relevant lipoic acid. Water is the only by-product generated during this reaction thus a very high atom economy is obtained. In addition, we have shown that the lipase can be recovered and reused several times without a significant loss of activity.
Secondary-Structure-Driven Self-Assembly of Reactive Polypept(o)ides: Controlling Size, Shape, and Function of Core Cross-Linked Nanostructures
Klinker, Kristina,Sch?fer, Olga,Huesmann, David,Bauer, Tobias,Capel?a, Leon,Braun, Lydia,Stergiou, Natascha,Schinnerer, Meike,Dirisala, Anjaneyulu,Miyata, Kanjiro,Osada, Kensuke,Cabral, Horacio,Kataoka, Kazunori,Barz, Matthias
, p. 9608 - 9613 (2017/08/01)
Achieving precise control over the morphology and function of polymeric nanostructures during self-assembly remains a challenge in materials as well as biomedical science, especially when independent control over particle properties is desired. Herein, we report on nanostructures derived from amphiphilic block copolypept(o)ides by secondary-structure-directed self-assembly, presenting a strategy to adjust core polarity and function separately from particle preparation in a bioreversible manner. The peptide-inherent process of secondary-structure formation allows for the synthesis of spherical and worm-like core-cross-linked architectures from the same block copolymer, introducing a simple yet powerful approach to versatile peptide-based core–shell nanostructures.
Photoinduced enhancement in the luminescence of hydrophilic quantum dots coated with photocleavable ligands
Impellizzeri, Stefania,McCaughan, Bridgeen,Callan, John F.,Raymo, Francisco M.
experimental part, p. 2276 - 2283 (2012/03/10)
In search of strategies to photoactivate the luminescence of semiconductor quantum dots, we devised a synthetic approach to attach photocleavable 2-nitrobenzyl groups to CdSe-ZnS core-shell quantum dots coated with hydrophilic polymeric ligands. The emission intensity of the resulting nanostructured constructs increases by more than 60% with the photolysis of the 2-nitrobenzyl appendages. Indeed, the photoinduced separation of the organic chromophores from the inorganic nanoparticles suppresses an electron-transfer pathway from the latter to the former and is mostly responsible for the luminescence enhancement. However, the thiol groups anchoring the polymeric envelope to the ZnS shell also contribute to the photoinduced emission increase. Presumably, their photooxidation eliminates defects on the nanoparticle surface and promotes the radiative deactivation of the excited quantum dots. This effect is fully reversible but its magnitude is only a fraction of the change caused by the photocleavage of the 2-nitrobenzyl groups. In addition, these particular quantum dots can cross the membrane of model cells and their luminescence increases by ～80% after the intracellular photocleavage of the 2-nitrobenzyl quenchers. Thus, photoswitchable luminescent constructs with biocompatible character can be assembled combining the established photochemistry of the 2-nitrobenzyl photocage with the outstanding photophysical properties of semiconductor quantum dots and the hydrophilic character of appropriate polymeric ligands.
RADIOLABELLED NANOPARTICLES
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Page/Page column 18-19, (2008/06/13)
The present invention relates to radiolabelled nanoparticles having a radioisotope non-covalently bonded thereto. The radiolabelled nanoparticles are useful as radiopharmaceuticals. Kits and methods of preparation of the radiolabelled nanoparticles are also disclosed.
Acyl Transfer from S-Monoacyldihydrolipoamide to Benzylamine in the Presence of Oxidizing Agents
Nambu, Yoko,Endo, Takeshi,Okawara, Makoto
, p. 815 - 817 (2007/10/02)
Acyl transfer reaction from N-benzyl-8-S-(p-nitrobenzoyl)dihydrolipoamide to benzylamine was enhanced with oxidizing agents such as cobalt(II) ion or a soluble flavin under an oxygen atmosphere or with di-4-pyridyl disulfide, accompanied by the formation
