758716-82-4

Basic information

• Product Name: 2-[(4-(trifluoromethyl)benzyl)thio]benzo[d]thiazole
• Synonyms: 2-[(4-(trifluoromethyl)benzyl)thio]benzo[d]thiazole
• CAS NO: 758716-82-4
• Molecular Weight: 325.378
• Mol File: 758716-82-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-[(4-(trifluoromethyl)benzyl)thio]benzo[d]thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-(trifluoromethyl)benzyl)thio]benzo[d]thiazole(758716-82-4)
• EPA Substance Registry System: 2-[(4-(trifluoromethyl)benzyl)thio]benzo[d]thiazole(758716-82-4)

Safety Data

• Hazardous Substances Data: 758716-82-4(Hazardous Substances Data)

Upstream product

• 149-30-4 2-Mercaptobenzothiazole 
• 939-99-1 4-trifluoromethylbenzyl chloride 
• 349-95-1 4-(trifluoromethyl)benzylic alcohol 

Downstream Products

• 1259948-51-0 2-((4-(trifluoromethyl)benzyl)sulfonyl)benzo[d]thiazole 

Relevant articles and documents

Green Synthesis of Potential Antifungal Agents: 2-Benzyl Substituted Thiobenzoazoles

A series of benzyl-substituted thiobenzoazoles were synthesized by an environmentally friendly approach, to search for new antifungal agrochemicals. Compounds were prepared starting from 2-mercaptobenzoazoles, using KOH, benzyl halides, and water, resulting in a simple and ecological method. New antifungals were tested against a group of phytopathogenic fungi. Two compounds showed an interesting activity against Botrytis cinerea, Fusarium oxysporum, and Aspergillus spp.: 2-((4-(trifluoromethyl)benzyl)thio)benzo[d]thiazole, 3ac, and 2-((4-methylbenzyl)thio)benzo[d]thiazole, 3al. Thus, 3ac and 3al can be considered as broad spectrum antifungal agents. Furthermore, two new compounds, 2-((4-iodobenzyl)thio)benzo[d]thiazole, 3aj, and 2-(benzylthio)benzo[d]oxazole, 3ba, showed better inhibitory effect against Botrytis cinerea and Fusarium oxysporum when compared to the commercial fungicide Captan. Thus, 3aj and 3ba can be considered reduced-spectrum antifungals.

One-pot sequential synthesis and antifungal activity of 2-(benzylsulfonyl)benzothiazole derivatives

New antifungal agrochemicals, derived from 2-(benzylsulfonyl)benzothiazole were synthesized by an environmentally friendly method, using water as reaction medium. These compounds were prepared by a one-pot, two-step synthesis, starting from 2-mercaptobenzothiazole and benzyl halides. The potential fungicides were tested against a panel of phytopathogenic fungi, with many of them showing a significant improvement compared to the non-oxidized analogues and the commercial antifungal Captan. The new derivatives 2-((2-chlorobenzyl)sulfonyl)benzo[d]thiazole (4f) and 2-((4-methylbenzyl)sulfonyl)benzo[d]thiazole (4k) presented remarkable properties, being able to inhibit the growth of two resistant moulds (Aspergillus fumigatus and Aspergillus ustus). Both 4f and 4k could be classified as broad-spectrum fungicides, emerging as possible candidates for the control of these moulds, which have negative impact in food production.

Structure-activity relationships of 2-benzylsulfanylbenzothiazoles: Synthesis and selective antimycobacterial properties

A set of 2-benzylsulfanyl derivatives of benzothiazole was synthesized and evaluated for antimicrobial and cytotoxic activities. The biological screening on antimicrobial activity against a panel of Gram-positive and Gramnegative bacteria, yeasts and fung