758719-49-2

Upstream product

• 758719-46-9 methyl (1R,3R,4R,5R)-5-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methylcyclohexane-1-carboxylate 
• 758719-55-0 methyl (1S,3R,4R,5R)-3-(tert-butyldiphenylsilyloxy)-6-hydroxy-5-methylcyclohexane-1-carboxylate 
• 758719-39-0 methyl (1R,3S,4R,5R)-5-(tert-butyldiphenylsilyloxy)-3-hydroxy-4-methylcyclohexane-1-carboxylate 
• 758719-47-0 (1S,3R,4S,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-methanesulfonyloxy-4-methyl-cyclohexanecarboxylic acid methyl ester 
• 758719-56-1 (1R,3R,4S,5R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-methanesulfonyloxy-4-methyl-cyclohexanecarboxylic acid methyl ester 
• 326622-28-0 (4R,6R)-6-acetoxy-1-methyl-4-(methoxycarbonyl)cyclohexene 
• 758719-38-9 methyl (1R,5R)-5-(tert-butyldiphenylsilyloxy)-4-methyl-3-cyclohexene-1-carboxylate 
• 758719-53-8 (1R,3R,4S,5R)-4-methyl-6-oxabicyclo[3.2.1]oct-7-one 
• 757240-15-6 (1R,5R)-5-Hydroxy-4-methyl-cyclohex-3-enecarboxylic acid methyl ester 
• 758719-52-7 (1R,5R)-4-methyl-6-oxabicyclo[3.2.1]oct-3-en-7-one 
• 326598-95-2 (1R,3S,4S,5R)-5-acetoxy-3-hydroxy-4-methyl-1-(methoxycarbonyl)cyclohexane 
• 758719-45-8 4-Nitro-benzoic acid (1R,2R,3R,5R)-3-(tert-butyl-diphenyl-silanyloxy)-5-methoxycarbonyl-2-methyl-cyclohexyl ester 
• 758719-48-1 methyl (1S,3R,4R,5S)-3-(tert-butyldiphenylsilyloxy)-4-methylbicyclo[3.1.0]hexane-1-carboxylate 
• 758719-54-9 (1R,3R,4S,5R)-3-(tert-butyldiphenylsilyloxy)-4-methyl-6-oxabicyclo[3.2.1]oct-7-one 

Downstream Products

• 758719-68-5 (1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(E)-ylidene]-2-methyl-cyclohexanol 
• 758719-67-4 (1R,2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-5-[2-[(1R,3aS,7aR)-1-((R)-5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methyl-cyclohexanol 
• 758719-37-8 1-[(1S,3R,4R,5S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-bicyclo[3.1.0]hex-1-yl]-2-[(1R,3aS,7aR)-1-[(R)-5-(1-ethoxy-ethoxy)-1,5-dimethyl-hexyl]-7a-methyl-octahydro-inden-(4E)-ylidene]-ethanol 

Relevant academic research and scientific papers

Synthesis of 2-methyl and ethyl-substituted 19-nor-1α,25- dihydroxyvitamin D3 analogues via the cyclovitamin strategy

The synthesis of several 19-nor-2-alkyl-1α,25-dihydroxyvitamin D 3 analogues (5-14) is described following the cyclovitamin strategy. Starting from all-cis methyl 3,5-dihydroxy-4-alkyl-1-cyclohexanecarboxylate (29), the eight stereoisomeric A-r

VITAMIN D ANALOGUES AND THEIR THERAPEUTIC USES

The present invention relates to analogues of vitamin D namely 14-epi-2-alkyl-19-nor vitamin D derivatives. Also a general method for the synthesis and the biological activities are described. The general formula is: (I) where R (alpha or beta oriented) r