75886-56-5Relevant academic research and scientific papers
Rapid catalyst identification for the synthesis of the pyrimidinone core of HIV integrase inhibitors
Bellomo, Ana,Celebi-Olcum, Nihan,Bu, Xiaodong,Rivera, Nelo,Ruck, Rebecca T.,Welch, Christopher J.,Houk, Kendall N.,Dreher, Spencer D.
supporting information; experimental part, p. 6912 - 6915 (2012/10/08)
A microscale chemistry improvement engine: A pre-dosed microscale high-throughput experimentation additives platform enables rapid, serendipitous reaction improvement. This platform allowed one chemist to set up 475 experiments and analyze the results using MISER chromatography in a single day, thus resulting in two high-quality catalytic systems for the construction of the title compound 1. Support for a single-electron transfer mechanism was obtained. Copyright
Reaction of Arylamidoximes with Dimethyl Acetylenedicarboxylate and Diethyl Chlorofumarate. Stereochemistry of the Adducts and the Derived 1,2,4-Oxadiazines (1).
Guzman, Angel,Romero, Susana,Urquiza, E. M. Guadalupe,Muchowski, Joseph M.
, p. 1101 - 1105 (2007/10/02)
It was shown that the addition of benzamidoxime to dimethyl acetylenedicarboxylate was predominantly cis-oid in methanol or acetonitrile solution and mainly trans-oid when benzene was the solvent.The stereochemistry of the cis-oid (4a) and trans-oid (5) a
