75894-95-0

Basic information

• Product Name: 1-amino-2-(3,5-dibromophenyl)ethane
• CAS NO: 75894-95-0
• Molecular Weight: 278.974
• Mol File: 75894-95-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-amino-2-(3,5-dibromophenyl)ethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-amino-2-(3,5-dibromophenyl)ethane(75894-95-0)
• EPA Substance Registry System: 1-amino-2-(3,5-dibromophenyl)ethane(75894-95-0)

Safety Data

• Hazardous Substances Data: 75894-95-0(Hazardous Substances Data)

Upstream product

• 188347-48-0 2-(3,5-dibromophenyl)acetonitrile 
• 145691-59-4 (3,5-dibromophenyl)methanol 
• 56908-88-4 3,5-dibromobenzyl bromide 

Relevant articles and documents

Antibacterial drug leads: DNA and enzyme multitargeting

We report the results of an investigation of the activity of a series of amidine and bisamidine compounds against Staphylococcus aureus and Escherichia coli. The most active compounds bound to an AT-rich DNA dodecamer (CGCGAATTCGCG)2 and using DSC were found to increase the melting transition by up to 24 °C. Several compounds also inhibited undecaprenyl diphosphate synthase (UPPS) with IC50 values of 100-500 nM, and we found good correlations (R2 = 0.89, S. aureus; R2 = 0.79, E. coli) between experimental and predicted cell growth inhibition by using DNA δTm and UPPS IC50 experimental results together with one computed descriptor. We also solved the structures of three bisamidines binding to DNA as well as three UPPS structures. Overall, the results are of general interest in the context of the development of resistance-resistant antibiotics that involve multitargeting.