75921-21-0

Basic information

• Product Name: alpha-D-Ribofuranose, 5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-
• Synonyms: alpha-D-Ribofuranose, 5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-
• CAS NO: 75921-21-0
• Molecular Formula: C₁₄H₂₈O₅Si
• Molecular Weight: 304.45
• Mol File: 75921-21-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: alpha-D-Ribofuranose, 5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-D-Ribofuranose, 5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-(75921-21-0)
• EPA Substance Registry System: alpha-D-Ribofuranose, 5-O-[(1,1-dimethylethyl)dimethylsilyl]-2,3-O-(1-methylethylidene)-(75921-21-0)

Safety Data

• Hazardous Substances Data: 75921-21-0(Hazardous Substances Data)

Upstream product

• 67814-68-0 2,3-O-isopropylidene-D-ribofuranose 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 70266-87-4 6-hydroxymethyl-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-ol 
• 23276-32-6 benzyl 2,3-O-isopropylidene-D-ribofuranoside 
• 32445-75-3 D-Ribose 
• 75921-19-6 Benzyl-5-O-tert-butyldimethylsilyl-2,3-O-isopropyliden-β-D-ribofuranosid 

Downstream Products

• 1054646-31-9 C₁₇H₂₃IO₅ 
• 1053258-42-6 C₂₁H₂₆O₅ 
• 1054633-43-0 C₂₈H₄₂O₅Si 
• 943151-02-8 C₂₀H₃₄O₄Si 
• 943151-03-9 C₂₀H₃₂O₄Si 
• 943150-92-3 C₂₂H₃₆O₄Si 
• 1053259-98-5 C₂₃H₃₈O₆Si 

Relevant articles and documents

TRICYCLIC-NUCLEOSIDE COMPOUNDS FOR TREATING VIRAL INFECTIONS

Disclosed are tricyclic nucleoside compounds of formula (I), and methods thereof for treating viral infections mediated at least in part by a Flaviviridae family virus.

Structure-activity relationships of 7-deaza-6-benzylthioinosine analogues as ligands of Toxoplasma gondii adenosine kinase

Several 7-deaza-6-benzylthioinosine analogues with varied substituents on aromatic ring were synthesized and evaluated against Toxoplasma gondii adenosine kinase (EC.2.7.1.20). Structure-activity relationships indicated that the nitrogen atom at the 7-position does not appear to be a critical structural requirement. Molecular modeling reveals that the 7-deazapurine motif provided flexibility to the 6-benzylthio group as a result of the absence of H-bonding between N7 and Thr140. This flexibility allowed better fitting of the 6-benzylthio group into the hydrophobic pocket of the enzyme at the 6-position. In general, single substitutions at the para or meta position enhanced binding. On the other hand, single substitutions at the ortho position led to the loss of binding affinity. The most potent compounds, 7-deaza-p-cyano-6- benzylthioinosine (IC50 = 5.3 μM) and 7-deaza-p-methoxy-6- benzylthioinosine (IC50 = 4.6 μM), were evaluated in cell culture to delineate their selective toxicity.

Formal total synthesis of ovalcin by carbohydrate approach

A formal total synthesis of ovalcin is described herein starting from readily available sugar ribose with selective zinc-mediated ring-opening reaction and Grubbs olefin metathesis as the key steps. Georg Thieme Verlag Stuttgart.