75924-41-3

Upstream product

• 123-54-6 acetylacetone 
• 95-53-4 o-toluidine 

Downstream Products

• 18441-61-7 2,4,8-trimethylquinoline 

Relevant academic research and scientific papers

Synthesis and structural characterization of trifluoromethyl-substituted β-ketoimino copper(II) complex and its catalytic behavior for methyl acrylate polymerization

A new trifluoromethyl-substituted bis(β-ketoimino)copper complex (II) was synthesized and characterized by FTIR, elemental analysis, and X-ray diffraction (CIF file CCDC no. 1023178). XRD refinement revealed that the copper complex adopted a perfect centr

A novel and reusable magnetic nanocatalyst developed based on graphene oxide incorporated strontium nanoparticles for the facial synthesis of β-enamino ketones under solvent-free conditions

A novel magnetic SrFeGO nanocatalyst (NC) was synthesized through a simple sol–gel technique by introducing strontium and iron oxide nanoparticles onto graphene. The synthesized NC was characterized using FT-IR and FE-SEM. Subsequently, the catalytic activity of SrFeGO was tested in a reaction between β-dicarbonyl compounds and aniline derivatives to gain β-enamino ketone derivatives under solvent-free conditions. It was found that SrFeGO NC is a potential catalyst for the synthesis of β-enamino ketones. The β-enamino ketone produced by such reactions could be isolated in high purity without the need for chromatographic purifications. The newly prepared magnetic graphene oxide nanocomposite could be recovered and reused for numerous times with no significant decrease in efficiency. Moreover, the protocol has the advantages of excellent yielding (up to 98%) in short a reaction time, benefitting an easy workup procedure and being environmentally friendly.

Oxo - nitrided iron complexes, said oxo - nitrided iron complexes including catalyst system, and [khen [khen] [cyu] gay [syen [syen] it became of dienes (hole) for the polymerization method (by machine translation)

The present invention refers to general formula (I) or (II) having oxo - nitrided iron complexes are disclosed. Said general formula (I) or (II) having oxo - [khen [khen] [cyu] gay [syen [syen] it became of dienes (ball) is nitrided iron complexes for the

OXO-NITROGENATED VANADIUM COMPLEX, CATALYTIC SYSTEM COMPRISING SAID OXO-NITROGENATED VANADIUM COMPLEX AND PROCESS FOR (CO)POLYMERISING CONJUGATED DIENES

An oxo-nitrogenated vanadium complex having the general formula (I): in which: —R1, R2, R3, R4, R5, R6 and R7, mutually identical or different, represent a hydrogen atom; or are selected from optionally halogenated, linear or branched C1-C20, preferably C

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

Nicotinamide N-methyltransferase (NNMT) is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. We have identified small molecule inhibitors of NNMT with >1000-fold range of activity and developed comprehensive structure-Activity relationships (SARs) for NNMT inhibitors. Screening of N-methylated quinolinium, isoquinolinium, pyrididium, and benzimidazolium/benzothiazolium analogues resulted in the identification of quinoliniums as a promising scaffold with very low micromolar (IC50 à 1 μM) NNMT inhibition. Computer-based docking of inhibitors to the NNMT substrate (nicotinamide)-binding site produced a robust correlation between ligand-enzyme interaction docking scores and experimentally calculated IC50 values. Predicted binding orientation of the quinolinium analogues revealed selective binding to the NNMT substrate-binding site residues and essential chemical features driving protein-ligand intermolecular interactions and NNMT inhibition. The development of this new series of small molecule NNMT inhibitors direct the future design of lead drug-like inhibitors to treat several metabolic and chronic disease conditions characterized by abnormal NNMT activity.

K-10 clay as a reusable catalyst for the solvent-free, MW-induced synthesis of enaminones

A series of β-amino-a,β-unsaturated ketones and esters were synthesized in good to excellent yields from the reaction of different amines with 1,3-dicarbonyl compounds in solvent-free media using montmorillonite K-10 clay as.

Solvent-free synthesis of N-Aryl-?β-Enaminones under microwave irradiation

A series of N-Aryl-?β-enaminones were efficiently prepared by acetylacetone reacted with substituted anilines in high yields without additional solvent under microwave irradiation. The most yields can reach over 80 %. Compared with traditional routes, thi

Simple and efficient synthesis of 3-aminopropenones and 3-aminopropenoates catalyzed by copper(II) nitrate trihydrate under solvent-free conditions

A simple, efficient and environmentally begin method has been developed for the synthesis of 3-aminopropenones and 3-aminopropenoates through the reaction of 1,3-dicarbonyl compounds with amines in the presence of Cu(NO 3)2 · 3H2O under solvent-free conditions.