75926-64-6

Upstream product

• 28232-30-6 2-(4'-chlorophenoxy)-5-nitropyridine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 535960-86-2 N-[6-(4-chlorophenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide 

Relevant academic research and scientific papers

Isothiazole compound and application thereof

The invention belongs to the field of agricultural fungicides and acaricides, and particularly relates to an isothiazole compound and an application thereof. The structural formula of the compound is as shown in the specification, and definitions of substituent group are indicated in instructions. The general compound has broad-spectrum bactericidal and insecticidal activity in the field of agriculture and excellent prevention and control effects on various germs such as corn rust diseases, rice blast, cucumber downy mildew and cucumber anthracnose. Particularly, the general compound has excellent prevention and treatment effects on the cucumber downy mildew and the cucumber anthracnose under low dosage. Besides, the partial compound has good acaricidal activity and can be used for preventing and treating tetranychus cinnabrinus and the like.

1, 5-naphthyridin deriv. contains, as an active component and insecticide

PROBLEM TO BE SOLVED: To provide a new compound having excellent agricultural/horticultural pest control power. SOLUTION: This naphthyridine compound is represented by formula (III). [In the formula, R1represents an alkyl group, a cyclic alkyl group or an alkyloxy group; X1and X2each represents a hydrogen atom or an alkyl group, or represent an alkylene group as one; X3and X4each represents a hydrogen atom, a halogen atom, an alkyl group or an alkyloxy group; Y1to Y5each represents a hydrogen atom, a halogen atom, a cyano group, an alkyl group, an alkyloxy group, an alkylthio group or an alkylenedioxy group; and Z2represents a halogen atom]. COPYRIGHT: (C)2013,JPO&INPIT

Therapeutic quinazoline derivatives

A compound of formula (I) or a salt, ester, amide or prodrug thereof; where X is O, or S, S(O), S(O)2 or NR6 where R6 is hydrogen of C1-6alkyl; R5 is an optionally substituted 6-membered aromatic ring containing at least one nitrogen atom, and R1, R2, R3, R4 are independently selected from halogeno, cyano, nitro, C1-3alkylsulphanyl, —N(OH)R7— (wherein R7 is hydrogen, or C1-3alkyl), or R9X1— (wherein X1 represents a direct bond, —O—, —CH2—, —OC(O), —C(O)—, —S—, —SO—, —SO2—, —NR10C(O)—, —C(O)NR11—, —SO2NR12—, —NR13SO2— or NR14— (wherein R10, R11, R12, R13 and R14 each independently represents hydrogen, C1-3alkyl or C1-3alkoxyC2-3alkyl), and R9 is hydrogen, optionally substituted hydrocarbyl, optionally substituted heterocyclyl or optionally substituted alkoxy; provided that at least one of R2 or R3 is other than hydrogen. These compounds inhibit aurora 2 kinase and are useful in the preparation of medicaments for the treatment of proliferative disease such as cancer.