75937-12-1

Basic information

• Product Name: TERT-BUTYL N-(6-HYDROXYHEXYL)CARBAMATE
• Synonyms: BOC-6-AMINOHEXANOL;BOC-AHX(6)-OL;BOC-ACP(6)-OL;BOC-NH-(CH2)6-OH;6-(BOC-AMINO)-1-HEXANOL;6-(TERT-BUTOXYCARBONYLAMINO)-1-HEXANOL;N-T-BUTOXYCARBONYL-6-AMINO-1-HEXANOL;N-T-BUTOXYCARBONYL-6-AMINO-AMINO-1-HEXANOL
• CAS NO: 75937-12-1
• Molecular Formula: C₁₁H₂₃NO₃
• Molecular Weight: 217.31
• Product Categories: Aliphatics;Miscellaneous Reagents
• Mol File: 75937-12-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 37-41 °C
• Boiling Point: 333.8°C at 760 mmHg
• Flash Point: 155.7°C
• Appearance: /
• Density: 0.987g/cm³
• Vapor Pressure: 9.48E-06mmHg at 25°C
• Refractive Index: 1.456
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 12.92±0.46(Predicted)
• BRN: 3604498
• CAS DataBase Reference: TERT-BUTYL N-(6-HYDROXYHEXYL)CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL N-(6-HYDROXYHEXYL)CARBAMATE(75937-12-1)
• EPA Substance Registry System: TERT-BUTYL N-(6-HYDROXYHEXYL)CARBAMATE(75937-12-1)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 75937-12-1(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Oil

Uses

Different sources of media describe the Uses of 75937-12-1 differently. You can refer to the following data:
1. Linker; preparation of the iodide
2. 6-(Boc-amino)-1-hexanol can be used as a reactant to synthesize:Hsp90 fluorescent probes applicable in the development of an FP assay for the Hsp90 chaperone.1-Guanidino-7-aminoheptane (GC7) analogs as potent deoxyhypusine synthase inhibitors.

InChI:InChI=1/C11H23NO3/c1-11(2,3)15-10(14)12-8-6-4-5-7-9-13/h13H,4-9H2,1-3H3,(H,12,14)

Upstream product

• 6404-29-1 6-(tert-butoxycarbonylamino)hexanoic acid 

Downstream Products

• 1256477-34-5 methyl 6-(3-(6-(tert-butoxycarbonylamino)hexyloxy)phenyl)picolinate 
• 118077-46-6 6,6'-disulfanediylbis(hexan-1-amine) dihydrochloride 
• 1338075-62-9 tert-butyl N-(6-hydroxyhexyl)-N-methylcarbamate 
• 1351533-96-4 (3S,4R)-phenyl 8-(tert-butoxycarbonylamino)-3-(4-chlorophenyl)-4-formyl-2-methyleneoctanoate 
• 1373558-72-5 tert-butyl-(6-(((4-nitrophenoxy)carbonyl)oxy)hexyl)carbamate 
• 1419639-24-9 tert-butyl (6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)carbamate 
• 1419639-25-0 2-(2-(4-((6-aminohexyl)oxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide 
• 1419639-26-1 C₅₄H₈₇N₉O₉ 
• 1419639-27-2 2,2',2''-(10-(2-((6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid 
• 1419687-42-5 gadolinium(III) 2,2',2''-(10-(2-(6-(4-(3-(2-(diethylamino)-2-oxoethyl)5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate 
• 50347-17-6 N-Methyl-6-hydroxyhexylamine 
• 1426395-22-3 6-[(tert-butoxycarbonyl)amino]hexyltriphenylphosphonium iodide 
• 1426395-23-4 Br^(1-)*C₃₂H₄₆NO₃P₂⁽¹⁺⁾ 
• 1426395-37-0 Br^(1-)*C₃₃H₄₈NO₃P₂⁽¹⁺⁾ 

Relevant articles and documents

Synthesis and evaluation of xanomeline analogs-Probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor

A series of xanomeline analogs were synthesized and evaluated for binding at the M1 muscarinic acetylcholine receptor (M1 receptor). Specifically, compounds that substitute the O-hexyl chain of xanomeline with polar, ionizable, or conformationally restricted moieties were assessed for their ability to bind to the M1 receptor in a wash-resistant manner (persistent binding). From our screen, several novel ligands that persistently bind to the M1 receptor with greater affinity than xanomeline were discovered. Results indicate that persistent binding may arise not only from hydrophobic interactions but also from ionic interactions with a secondary M1 receptor binding site. Herein, a qualitative model that accounts for both binding scenarios is proposed and applied to understand the structural basis to wash-resistant binding and long-acting effects of xanomeline-based compounds.

Non-Peptide Fibrinogen Receptor Antagonists. 2. Optimization of a Tyrosine Template as a Mimic for Arg-Gly-Asp

Inhibitors of platelet-fibrinogen binding offer an opportunity to interrupt the final, common pathway for platelet aggregation.Small molecule inhibitors of the platelet fibrinogen receptor GPIIb/IIIa were prepared and evaluated for their ability to prevent platelet aggregation.Compound 23m (L-700, 462/MK-383) inhibited in vitro platelet aggregation with an IC50 of 9 nM and demonstrated a selectivity of >24000-fold between platelet and human umbilical vein endothelial cell fibrinogen receptors.Dose-dependent inhibition of ex vivo platelet aggregation induced by ADP was achieved with iv infusions 0.1-10 μg/kg/min of 23m in anesthetized dogs, with 10 μg/kg/min completely inhibiting platelet aggregation during the entire 6 h infusion protocol.Platelet aggregatability returned rapidly after the termination of the 23m infusions.These features suggest that 23m may be useful in the treatment of arterial occlusive disorders.