75939-72-9

Upstream product

• 75939-71-8 1-(Trimethylsilyl)-4-tritylthio-2-azetidinone 
• 75-07-0 acetaldehyde 
• 108-18-9 diisopropylamine 
• 4111-54-0 lithium diisopropyl amide 

Downstream Products

• 87996-94-9 racemic (3S,4R)-1-(allyloxycarbonyl)methyl-3-((R)-1-t-butyldimethylsilyloxyethyl)-4-triphenylmethylthio-2-azetidinone 
• 87996-96-1 racemic (3S,4R)-1-(allyloxycarbonyl)methyl-3-<((R)-1-t-butyldimethylsilyloxy)-ethyl>-4-phenoxy(thiocarbonyl)thio-2-azetidinone 
• 87996-98-3 Silver; (2S,3R)-3-[(S)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(4-nitro-benzyloxycarbonylmethyl)-4-oxo-azetidine-2-thiolate 
• 87996-95-0 racemic (3S,4R)-1-(p-nitrobenzylcarbonyl)methyl-3-((R)-1-t-butyldimethylsilyloxyethyl)-4-triphenylmethylthio-2-azetidinone 
• 87996-99-4 racemic (3S,4R)-1-(p-nitrobenzyloxycarbonyl)methyl-3-<((R)-1-t-butyldimethylsilyloxy)-ethyl>-4-phenoxy(thiocarbonyl)thio-2-azetidinone 
• 80926-64-3 racemic p-nitrobenzyl (3S,5R,6S)-6-((R)-1-(t-butyl-dimethylsilyloxy)ethyl)-2-thioxopenam-3-carboxylate 
• 87997-02-2 racemic p-nitrobenzyl (5R,6S)-6-((R)-1-(t-butyl-dimethylsilyloxy)ethyl)-2-methylthiopenem-3-carboxylate 
• 87996-93-8 racemic (3S,4R)-3-((R)-1-(t-butyldimethylsilyloxy)ethyl)-4-triphenylmethylthio-2-azetidinone 

Relevant academic research and scientific papers

Antibacterial agents, and 4-thio azetidinone intermediates

This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula STR1 wherein Y is hydrogen, halo or certain organic substituents and X represents certain organic substituents. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.

2,6-Disubstituted penem compounds

This invention relates to 2-substituted and 2,6-disubstituted penem compounds of the formula STR1 wherein Y is hydrogen, halo or certain organic radicals and X represents certain hetero-interrupted substituted alkyl radicals. Also included in the invention are pharmaceutically acceptable salts of the above compounds and derivatives of the above compounds in which the carboxyl group at the 3-position is protected as by an easily removable ester protecting group. The compounds of the present invention are potent antibacterial agents or are of use as intermediates in the preparation of such agents.