7594-49-2

Usage

Uses

Used in Organic Synthesis:
1,1-BIS(TRIFLUOROMETHYL)-2,2,2-TRICHLOROETHANOL is used as a solvent for facilitating various chemical reactions in organic synthesis. Its high reactivity allows it to be a versatile component in the creation of different organic compounds.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 1,1-BIS(TRIFLUOROMETHYL)-2,2,2-TRICHLOROETHANOL is used as a solvent in the synthesis of various drugs. Its properties make it suitable for the production of specific medicinal compounds.
Used in Healthcare Industry as a Preservative and Disinfectant:
1,1-BIS(TRIFLUOROMETHYL)-2,2,2-TRICHLOROETHANOL is used as a preservative and disinfectant due to its antimicrobial properties. It helps in maintaining sterility and preventing microbial contamination in healthcare settings.

InChI:InChI=1/C4HCl3F6O/c5-2(6,7)1(14,3(8,9)10)4(11,12)13/h14H

Upstream product

• 650-51-1 sodium trichloroacetate 
• 684-16-2 Hexafluoroacetone 
• 76-03-9 trichloroacetic acid 
• 56-23-5 tetrachloromethane 
• 1515-14-6 1,1,1,3,3,3-hexafluoro-2-methylpropan-2-ol 

Downstream Products

• 2378-02-1 1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-ol 

Relevant academic research and scientific papers

Synthesis and physicochemical properties of poly(perfluoro-2-trichloromethylisopropyl acrylate)

A new acrylic monomer derived from perfluoro-2-trichloromethylisopropanol was synthesized. Poly(perfluoro-2-trichloromethylisopropyl acrylate) was prepared by radical bulk polymerization, and its physicochemical properties were studied. It was found that the prepared polyacrylate can be used to manufacture optical waveguides.

Structural and solvent effects on rates of solvolysis of secondary alkyl substrates - An update

Rate constants for solvolyses of secondary alkyl tosylates in fluorinated media [including hexafluoropropan-2-ol (HFIP), hexafluoroacetone sesquihydrate, and trichloromethylbis(trifluoromethyl)carbinol] are reported. Rates of solvolysis of 2-adamantyl p-toluenesulfonate in 97% (w/w) HFIP-water at 25°C are neither retarded by the addition of NaOTs nor accelerated greatly by NaClO4). The α-deuterium kinetic isotope effect for solvolyses of 1-(1-adamantyl)ethyl methanesulfonate in 20% acetone-water at 25°C is 1.14. Mechanistic implications of these results are discussed. Copyright

TRICHLOROMETHYLATION OF FLUOROKETONES

The nuclophilic trichloromethylation of fluoroketones was carried out by the reductive addition of CCl4 in the presence of aluminum or by the reaction of trichloroacetic acid in HMPTA.The trichloromethylcarbinols obtained were used in the synthesis of perfluorinated tertiary alcohols and trifluoromethylated 1,1-dichlorooxiranes. Keywords: fluoroketones, trichloromethylation, fluorine-containing trichloromethylcarbinols and 1,1-dichlorooxiranes, synthesis.