75949-45-0Relevant academic research and scientific papers
Synthesis and characterization of a series of isomeric oxotechnetium(V) diamido dithiolates
Brenner, David,Davison, Alan,Lister-James, John,Jones, Alun G.
, p. 3793 - 3797 (2008/10/08)
The diamido dithiolato technetium complexes [TcO(SCH2CONCH2CONCH2CH2S)] - and [TcO(SCH2CH2NCO)2]- have been prepared both via dithionite reduction of TcO4- and by ligand exchange from [TcO(OCH2CH2O)2]-. The synthesis and characterization of the complexes and their precursor ligands are presented. The highly stereoselective deuterium exchange of the active methylenes of [TcO(SCH2CONCH2CONCH2CH2S)] - is discussed. The application of this chemistry to radiopharmaceuticals is considered.
A new class of oxotechnetium(5+) chelate complexes containing a TcON2S2 core
Davison, Alan,Jones, Alun G.,Orvig, Chris,Sohn, Miriam
, p. 1629 - 1632 (2008/10/08)
The benzoyl-protected dimercaptodiamides (PhCOS(CH2)nCONH)2X (n = 1, X = (CH2)2, (CH2)3, and o-C6H4; n = 2, X = (CH2)2 and (CH2)3) have been synthesized. From these, via the sodium dithionite reduction of TcO4- in base, the technetium complexes [TcO(S(CH2)nCONXNCO(CH2)nS)] - (n = 1, X = (CH2)2, (CH2)3, and o-C6H4; n = 2, X = (CH2)2) have been prepared. The synthesis and characterization of the complexes, and their precursors, are presented, and the radiopharmaceutical applicability is discussed.
