75950-50-4Relevant academic research and scientific papers
Convenient Syntheses of Alkyl β-Resorcylate Derivatives
Barrett, Anthony G. M.,Morris, Timothy M.,Barton, Derek H. R.
, p. 2272 - 2277 (2007/10/02)
Syntheses of methyl 2,4-dihydroxy-6-methyl- (1a) and -3,6-dimethylbenzoates (1b) and methyl 2,4-dihydroxy-6-pentylbenzoate (1c) are described.Condensation reactions of dimethyl sodiomalonate with the dianion derived from pentane-2,4-dione or the dimerisation of the methyl acetoacetate dianion or the acetylation of the trianion derived from methyl 3,5,7-trioxo-octanoate gave (1a) (78percent) after work-up at pH 9.Analogous convenient, short, optimised syntheses of (1b and c) are given in detail.
