75959-08-9

Basic information

• Product Name: 8-METHOXYQUINOLIN-6-AMINE
• Synonyms: 8-METHOXYQUINOLIN-6-AMINE;6-Amino-8-methoxyquinoline;6-QuinolinaMine, 8-Methoxy-
• CAS NO: 75959-08-9
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.1992
• Mol File: 75959-08-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-METHOXYQUINOLIN-6-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHOXYQUINOLIN-6-AMINE(75959-08-9)
• EPA Substance Registry System: 8-METHOXYQUINOLIN-6-AMINE(75959-08-9)

Safety Data

• Hazardous Substances Data: 75959-08-9(Hazardous Substances Data)

Usage

General Description

8-Methoxyquinolin-6-amine, also known as 6-amino-8-methoxyquinoline, is an organic compound that belongs to the class of quinoline derivatives. It is an aromatic amine with a molecular formula of C10H10N2O, and a molecular weight of 174.20 g/mol. This chemical compound is mainly used in the development of pharmaceuticals, agrochemicals, and other organic synthesis. It has also been identified as a potential inhibitor of several enzymes, making it a subject of interest in the field of medicinal chemistry. Its unique structure and properties make it a valuable ingredient in the production of various chemical products.

Upstream product

• 97-52-9 2-methoxy-4-nitrophenylamine 
• 88609-18-1 6-azido-8-methoxyquinoline 
• 865-47-4 potassium tert-butylate 
• 865-33-8 potassium methanolate 
• 80912-11-4 8-methoxy-6-nitroquinoline 

Downstream Products

• 951-06-4 5-methoxy-[4,7]phenanthroline 

Relevant articles and documents

Synthesis of mono-substituted derivatives of 6-aminoquinoline

Several 6-aminoquinoline derivatives, which could be used in drug design, have been synthesized. The reaction conditions were comparatively studied, and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Von Miller reaction. The nitro group was reduced effectively by SnCl2 with no halo-removed occurred.

The Photo-induced Ring Expansion of Azido(methoxy)quinolines to Methoxypyridoazepines

The yield of 9-alkylamino-5H-pyridoazepines from the photo-induced ring-expansion of 8-azidoquinoline in primary amines are increased significantly by the presence of a 6-methoxy group, which also for the first time induces ring-expansion of the azide in secondary amines.Optimum conditions have been found for the ring-expansion of 8-azidoquinoline in methanol-potassium methoxide to give 9-methoxy-5H-pyridoazepine, and under the same conditions 8-azido-6-methoxy- and 6-azido-8-methoxy-quinoline ring-expand in excellent yield to the corresponding dimethoxypyridoazepines.