75971-32-3

Upstream product

• 226075-10-1 4-chloro-N-(4-fluorobenzyl)-2-nitroaniline 
• 89-61-2 2,5-dichloronitrobenzene 
• 140-75-0 para-fluorobenzylamine 

Downstream Products

• 73733-86-5 ethyl 4-<<<<5-chloro-2-<<(4-fluorophenyl)methyl>amino>phenyl>amino>thioxomethyl>amino>-1-piperidinecarboxylate 
• 130212-26-9 5-chloro-1-(p-fluorophenylmethyl)-2(1H)-benzimidazolone 
• 1137840-33-5 4-[5-chloro-1-(4-fluorobenzyl)-1H-benzimidazole-2-yl]benzoic acid 
• 73734-47-1 5-chloro-1-<(4-fluorophenyl)methyl>-N-<1-(2-phenylethyl)-4-piperidinyl>-1H-benzimidazol-2-amine 
• 73755-75-6 ethyl 4-<<5-chloro-1-<(4-fluorophenyl)methyl>-1H-benzimidazol-2-yl>amino>-1-piperidinecarboxylate 
• 130212-28-1 2,5-dichloro-1-(p-fluorophenylmethyl)-1H-benzimidazole 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of some novel 2-[4-(substituted piperazin-/piperidin-1-ylcarbonyl)phenyl]- 1 H-benzimidazole derivatives

In this study, we report the synthesis and antimicrobial evaluation of several new 4-(1H-benzimi-dazol-2-yl)benzamides (11 - 30) and 5-chloro-1-(p-fluorobenzyl)-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl} -1H-benzimidazole (33). Compound 20 exhibited the best antibacterial activity with MIC value of 6.25 μg/mL against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). Significant antifungal activities were obtained with the compounds 13, 14, 18, 19, and 33 with MIC values of 3.12 μg/mL which are close to fluconazole.

Synthesis of 1,2,5(6)-trisubstituted benzimidazoles and evaluation of their antimicrobial activities

A series of 22 benzimidazoles, having several substituents on the azole and benzene nuclei, were prepared and evaluated in vitro for antimicrobial activity. At first 2-chloro or 2-chloromethyl-5(6)-substituted-1H-benzimidazoles were synthesized, which wer

New Antihistaminic N-Heterocyclic 4-Piperidinamines. 2. Synthesis and Antihistaminic Activity of 1--N-(4-piperidinyl)-1H-benzimidazol-2-amines

The synthesis of a series of 1--N-(4-piperidinyl)-1H-benzimidazol-2-amines and the preliminary evaluation of their in vivo antihistamine activity are described.The title compounds were obtained starting from either 1, 4, 10, or 55 by different synthetic methods.Substitution on the phenyl nucleus of the benzimidazole ring (84-87) was achieved by two different approaches.The in vivo antihistamine activity was evaluated by the compound 48/80 induced lethality test in rats and the antihistamine-induced lethality test in guinea pigs after oral and/o r subcutaneous administration.The duration of action was studied in the guinea pig for three compounds (4, 51, and 55).Compound 51, "astemizole", was also studied in histamine- and serotonin-induced cutaneous reaction and for mydriatic activity in the rat and tested for peripheral and central effects not related to histamine antagonism in a variety of systems.Astemizole has been selected for clinical investigation.