7598-20-1Relevant articles and documents
Synthesis and pharmacological evaluation of 1,1,3-substituted urea derivatives as potent TNF-α production inhibitors
Enomoto, Hiroshi,Sawa, Ayako,Suhara, Hiroshi,Yamamoto, Noriyoshi,Inoue, Hiroyuki,Setoguchi, Chikako,Tsuji, Fumio,Okamoto, Masahiro,Sasabuchi, Yoshimasa,Horiuchi, Masato,Ban, Masakazu
scheme or table, p. 4479 - 4482 (2010/10/02)
A three substituted urea derivative, SA13353 (compound 1a), exhibited potent inhibitory activity against lipopolysaccharide (LPS)-induced TNF-α production. We focused on the 1,1-substituted moiety (R1 and R 2) of SA13353 and investigated substituent effects of this moiety on LPS-induced TNF-α production by oral administration in rats. The synthesis of the urea derivatives was performed rapidly in a one-pot manner using a manual synthesizer. Several compounds containing hydrophobic substituents at this moiety showed more potent inhibitory activities than SA13353.