75985-58-9Relevant academic research and scientific papers
REACTIONS OF AZIRIDINE-2-CARBOXYLIC ACID DERIVATIVES WITH ESTERS AND NITRILES OF UNSATURATED ACIDS
Trapentsier, P. T.,Kalvin'sh, I. Ya.,Liepin'sh, E'. E'.,Lukevits, E'. Ya.
, p. 391 - 394 (2007/10/02)
Products of addition to the multiple bond were obtained in the reaction of the methyl ester, nitrile, and amide of aziridine-2-carboxylic acid with esters or nitriles of acrylic acid and esters of maleic, acetylenemonocarboxylic, and acetylenedicarboxylic acids.The bromination of 1-(2-alkoxycarbonylethenyl)-2-methoxycarbonylaziridines under various conditions leads to the addition of bromine to the multiple bond with retention or opening of the aziridine ring.
N-Substituted aziridine-2-carboxylic acid derivatives and their immuno-stimulation compositions and methods
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, (2008/06/13)
A 2-cyanaziridine derivative of the formula STR1 wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms, which is substituted by an aromatic nitrogen-containing heterocyclic radical with 5 or 6 ring-members and 1, 2 or 3 nitrogen atoms optionally substituted by halogen, alkoxy with up to 8 carbon atoms, alkyl with up to 8 carbon atoms, hydroxyl, carbalkoxy with up to 9 carbon atoms, carbamoyl, dialkylamino the alkyl moieties of which having up to 8 carbon atoms, cycloalkylamino, the cycloalkyl moiety having 3-10 carbon atoms, acetylamino, nitro, cyano, acetyl, alkylthio with up to 8 carbon atoms, alkylsulphinyl with up to 8 carbon atoms, alkylsulphonyl with up to 8 carbon atoms, sulphamoyl, phenyl, trifluoromethyl, phenoxy, acetoxy or methylenedioxy; or a pharmacologically acceptable salt thereof, exhibits immune stimulating activity.
N-Substituted aziridine-2-carboxylic acid derivatives for immuno stimulation
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, (2008/06/13)
Aziridine-2-carboxylic acid derivatives of the formula STR1 wherein X is a carboxyl, nitrile, alkoxycarbonyl or carbamoyl group, and R and R1 are various organic radicals, or pharmacologically acceptable salts thereof, exhibit marked immunostimulant activity, especially in conjunction with added chemotherapeutic agents such as a penicillin, a cephalosporin, a nitrofuran or chloramphenicol. Those compounds are new where X is a cyano group or an alkoxycarbonyl radical and R1 is a hydrogen atom, but R' is not an unsubstituted alkyl radical or an alkyl radical substituted by hydroxyl, alkoxy, dialkylamino, phenyl, 4-chlorophenyl or 4-methoxyphenyl or a vinyl radical substituted by a phenyl or methyl radical, or a cycloalkyl radical, a phenyl a 4-chlorophenyl, a 4-methoxyphenyl, an s-triazinyl or a pyridinyl radical; or where X is a carbamoyl group and R1 is a hydrogen atom, R' is not an unsubstituted cyclohexyl, alkyl or benzyl radical; or where X is a cyano group or an alkoxycarbonyl radical and R1 is a phenyl radical, R' is not an isopropyl, cyclohexyl, phenyl, benzyl or p-chlorobenzyl radical; or where R1 is a methyl radical, R1 is not a benzyl, p-chloro- or p- methoxybenzyl radical.
