75987-08-5 Usage
General Description
2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid is a chemical compound with the molecular formula C19H17NO2. It is a derivative of the amino acid phenylalanine and is commonly known as febuxostat. Febuxostat is a xanthine oxidase inhibitor that is used to treat symptoms of gout by lowering the levels of uric acid in the blood. It works by blocking the action of xanthine oxidase, the enzyme responsible for the production of uric acid. Febuxostat is available in oral tablet form and is typically prescribed for long-term management of chronic gout. It is important to follow the prescribed dosage and instructions when using febuxostat to prevent potential side effects and interactions with other medications.
Check Digit Verification of cas no
The CAS Registry Mumber 75987-08-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,5,9,8 and 7 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 75987-08:
(7*7)+(6*5)+(5*9)+(4*8)+(3*7)+(2*0)+(1*8)=185
185 % 10 = 5
So 75987-08-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H15NO2/c1-12(16(18)19)9-13-4-6-14(7-5-13)10-15-3-2-8-17-11-15/h2-9,11H,10H2,1H3,(H,18,19)/b12-9+
75987-08-5Relevant articles and documents
Highly Selective Inhibitors of Thromboxane Synthetase. 2. Pyridine Derivatives
Tanouchi, Tadao,Kawamura, Masanori,Ohyama, Isao,Kajiwara, Ikuo,Iguchi, Yohichi,et al.
, p. 1149 - 1155 (2007/10/02)
The enzyme thromboxane (TX) synthetase is inhibited by pyridine.The β-substituted pyridine derivatives showed higher inhibitory potency than γ-substituted ones having the side chain.Among the β-substituted derivatives containing the ω-carboxyalkyl group, the compounds with 6-8 carbon atoms in the side chain were especially effective.The derivatives holding the phenylene group in the side chain exhibited much higher inhibitory activity than those of the alkylene type.Among them, (E)-3--2-methylacrylic acid hydrochloride (5a) had the highest potency (IC50 = 3*10-9 M).The β-substituted pyridine derivatives and 1-substituted imidazole derivatives which had the same side chain showed almost the same potency.The β-substituted pyridine derivatives do not inhibit arachidonic acid cyclooxygenase or prostaglandin I2 synthetase, two other enzymes of the arachidonic cascade.
