75988-60-2

Upstream product

• 75988-65-7 4-oxocyclopent-2-enyl N-phenylcarbamate 

Downstream Products

• 75988-61-3 N-(4-oxocyclopent-2-enyl)-NN'-diphenylurea 
• 75988-68-0 2,4-diphenyl-3-thioxo-2,4-diaza-cis-bicyclo<3.3.0>octan-7-one 
• 75988-62-4 2,4-diphenyl-2,4-diaza-cis-bicyclo<3.3.0>octane-3,7-dione 

Relevant academic research and scientific papers

IMPROVEMENTS IN PHARMACEUTICALLY USEFUL COMPOUNDS

A compound of formula (I) or (II): wherein A is hydrogen or CR1R2; Y and Z are each, independently, hydrogen or a halogen;X is -NR4R5, or R7; R1 is hydrogen, or a substituted or unsubstituted alkyl or alkenyl group containing 1-4 carbon atoms; when X is -NR4R5, R2 is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1-12 carbon atoms; when X is R7, R2 is an unsubstituted alkyl, alkenyl or alkynyl group, or a substituted or unsubstituted aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1-12 carbon atoms; R3 is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1-12 carbon atoms; R4 is hydrogen, a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, aralkyl aralkenyl, or aralkynyl group, that optionally includes at least one heteroatom in its carbon skeleton and contains 1-12 carbon atoms, -COOR8, or -COR8; R5 is hydrogen, or a substituted or unsubstituted alkyl or alkenyl group containing 1-5 carbon atoms; R7 is an unsubstituted alkyl, alkenyl, or alkynyl group, that contains 1-4 carbon atoms; and, R8 is an unsubstituted or halo-substituted alkyl, aryl, or aralkyl group, that contains 1-12 carbon atoms.

Synthesis of 2,4-Diazabicyclooctane-3,7-diones and 3-Thioxo-2,4-diazabicyclooctan-7-one by an Intramolecular Michael-type Reaction. Stability of 2,4 Diaza-, 4-Oxa-2-aza-, and 4-Thia-2-aza-bicyclooctane-3,7-diones

Novel 2,4-diazabicyclooctane-3,7-diones (10) have been prepared by an intramolecular Micael-type cyclisation.The analogous 3-thioxo-2,4-diazabicyclooctan-7-one system (20) is obtained by base-catalysed retro-Michael reaction of the less stable 3-arylimino-2-thia-4-azabicyclooctan-7-one isomer (19).The 2-aza-4-oxabicyclooctane-3,7-dione system (17) is shown to be very unstable to base, fragmenting via the carbamic acid to give carbon dioxide and a 4-N-substituted cyclopent-2-enone (11).The relative stability to base of these bicyclic systems is correlated with their structure.