75997-84-1Relevant academic research and scientific papers
Synthesis and pharmacological evaluation of 2-(2 and 4- pyridinyl)indane-1,3-diones and structuraly related compounds exerting potential anti-inflammatory and antitumoral activities
Robert-Piessard,Leblois,Courant,Baut,Petit
, p. 160 - 168 (2007/10/03)
Our on going work in the series of enamido-diketones issued from 2- azaarylindane-1,3-diones led us to synthesize and experiment N and C2- substituted derivatives of 2-(2 and 4-pyridinyl)indane-1,3-diones as well as of structurally related compounds resulting from the replacement of pyridine by quinoline and benzimidazole. Pharmacological evaluation of their anti- inflammatory activity (by inhibition of carrageenan foot edema) and their anticoagulant activity (by prothombin assay) led to the conclusion of the possibility of achieving a selective antiinflammatory effect. It has been previously established that anticoagulants are liable to exert a protective effect in the development of cancer metastasis. Nevertheless none of the six experimented 2-(pyridin-2-yl)indane-1,3-diones extended survival time of mice treated by P388 lymphocytic leukemia.
β-Diceto enamines heterocycliques: 1. Indanediones-1,3 substituees en 2 par un heterocycle azote
Ploquin, J.,Sparfel, L.,Baut, G. Le,Floc'h, R.,Letourneux, Y.
, p. 961 - 973 (2007/10/02)
The condensation of methylated N-heterocycles and especially monomethyl- and polymethylpyridines on phthalic anhydrides leads to 2-aryl-1,3-indanediones.The 3-alkylidenylphthalides formed in an intermediary state have been isolated.The influence of solvents and temperature on the velocity and yield of formation of 2-(2- and 4-pyridyl)-1,3-indandiones has been studied.The ir and nmr spectra confirm that these compounds exist under a β-diketoenamine form resonating with a betaine form.
