76-28-8 Usage
Uses
Used in Pharmaceutical Industry:
11α-Hydroxydigitoxigenin is used as an active pharmaceutical ingredient for the treatment of heart conditions, particularly congestive heart failure. Its application is based on its ability to increase the force of myocardial contractions and modulate the cardiovascular system.
Used in Research Applications:
In the field of research, 11α-Hydroxydigitoxigenin serves as a valuable compound for studying the structure-activity relationships of cardenolides and their potential therapeutic applications. It aids scientists in understanding the mechanisms of action and the development of new drugs based on its chemical structure.
Used in Drug Development:
11α-Hydroxydigitoxigenin is utilized in drug development as a lead compound for the creation of new medications targeting various diseases. Its unique properties and potential to modulate biological processes make it a promising candidate for the development of innovative therapeutic agents.
Used in Toxicological Studies:
Due to its inherent toxicity, 11α-Hydroxydigitoxigenin is also used in toxicological studies to understand the effects of cardenolides on biological systems. This knowledge is crucial for the safe application of these compounds in medicine and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 76-28-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 6 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 76-28:
(4*7)+(3*6)+(2*2)+(1*8)=58
58 % 10 = 8
So 76-28-8 is a valid CAS Registry Number.
InChI:InChI=1/C23H34O5/c1-21-7-5-15(24)10-14(21)3-4-17-20(21)18(25)11-22(2)16(6-8-23(17,22)27)13-9-19(26)28-12-13/h9,14-18,20,24-25,27H,3-8,10-12H2,1-2H3/t14-,15+,16-,17-,18-,20-,21+,22-,23+/m1/s1
76-28-8Relevant academic research and scientific papers
Corchorusosides A, B, C, D, and E, new cardiotonic oligoglycosides from the seeds of Corchorus olitorius L. (Moroheiya)
Yoshikawa, Masayuki,Murakami, Toshiyuki,Shimada, Hiromi,Fukada, Nobuyuki,Matsuda, Hisashi,Sashida, Yutaka,Yamahara, Johji
, p. 869 - 873 (2007/10/03)
The methanolic extract of the seeds of Corchorus olitorius L. (Moroheiya) was found to show inhibitory effect against Na+,K+-ATPase and positive inotropic activity in the guinea pig isolated atria. Through bioassay-guided separation from the methanolic extract, new cardenolide oligoglycosides called corchorusosides A, B, C, D, and E were isolated together with six known cardenolide oligoglycosides. The structures of new corchorusosides were determined on the basis of chemical and physicochemical evidence. All cardenolide oligoglycosides from the seeds showed potent inhibitory activity against Na+,K+-ATPase, which was equivalent to those of digitoxin and ouabain. The methanolic extract, glycoside fraction, and principal glycoside showed potent acute toxicity by intraperitoneal administration, whereas they showed little acute toxicity by oral administration. Furthermore, by means of HPLC quantitative analysis of the cardiotonic oligoglycosides, it was found that the glycosides mainly distributed in the seeds , while the edible parts such as fresh young leaves and stems contained only trace amount.
