76010-63-4

Upstream product

• 368-77-4 3-trifluoromethylbenzonitrile 
• 52059-77-5 2-(2-oxo-1,3,4-oxathiazol-5-yl)benzonitrile 
• 17174-98-0 o-cyanobenzamide 

Downstream Products

• 76010-65-6 2-<5-<3-(trifluoromethyl)phenyl>-1,2,4-thiadiazol-3-yl>benzamide 
• 76010-67-8 methyl 2-<5-<3-(trifluoromethyl)phenyl>-1,2,4-thiadiazol-3-yl>benzoate 

Relevant academic research and scientific papers

NITRILE SULFIDES. SYNTHESIS OF 2-(1,2,4-THIADIAZOLYL)BENZOATES AND 2-(1,2,4-THIADIAZOLYL)BENZONITRILES

1,3-Dipolar cycloadditions of aromatic nitrile sulfides to methyl o-cyanobenzoate and to phthalonitrile gave methyl 2-(3-aryl-1,2,4-thiadiazol-5-yl)benzoates 6a-c and 2-(3-phenyl-1,2,4-thiadiazol-5-yl)benzonitrile (7).Cycloaddition of 2-cyanobenzonitrile sulfide to aromatic nitriles gave 2-(5-aryl-1,2,4-thiadiazol-3-yl)benzonitriles 11a,b, which were converted to methyl 2-(5-aryl-1,2,4-thiadiazol-3-yl)benzoates 13a,b.Yields of the cycloadducts are increased by dilution of the reaction mixtures with a nonpolar solvent.