760144-55-6 Usage
Uses
Used in Drug Discovery and Development:
Imidazo[1,2-a]pyridine-8-carboxylic acid, 6-chloro-, methyl ester is used as a key intermediate in the synthesis of biologically active compounds for drug discovery and development. Its unique structure and potential biological activities contribute to the design and development of novel therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Imidazo[1,2-a]pyridine-8-carboxylic acid, 6-chloro-, methyl ester is utilized as a building block for the synthesis of various pharmaceutical compounds. Its chemical properties and reactivity make it suitable for the creation of new molecules with potential therapeutic applications.
Used in Chemical Synthesis:
Imidazo[1,2-a]pyridine-8-carboxylic acid, 6-chloro-, methyl ester is used as a versatile reagent in chemical synthesis processes. Its functional groups and chemical properties allow for the formation of a wide range of chemical products, making it a valuable component in various chemical industries.
It is important to handle and use Imidazo[1,2-a]pyridine-8-carboxylic acid, 6-chloro-, methyl ester with care, following proper safety protocols and guidelines to prevent any potential hazards. Its applications in various industries highlight the significance of Imidazo[1,2-a]pyridine-8-carboxylic acid, 6-chloro-, methyl ester in the development of new and innovative products.
Check Digit Verification of cas no
The CAS Registry Mumber 760144-55-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,6,0,1,4 and 4 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 760144-55:
(8*7)+(7*6)+(6*0)+(5*1)+(4*4)+(3*4)+(2*5)+(1*5)=146
146 % 10 = 6
So 760144-55-6 is a valid CAS Registry Number.
760144-55-6Relevant academic research and scientific papers
Becker, Daniel P.,Flynn, Daniel L.,Moormann, Alan E.,Nosal, Roger,Villamil, Clara I.,Loeffler, Richard,Gullikson, Gary W.,Moummi, Chafiq,Yang, Dai-C.
, p. 1125 - 1139 (2006)
A series of pyrrolizidine esters, amides, and ureas was prepared and tested for 5-HT4 and 5-HT3 receptor binding, 5-HT4 receptor agonism in the rat tunica muscularis mucosae (TMM) assay, and for 5-HT3 receptor-mediated functional antagonism in the Bezold-Jarisch reflex assay. Several pyrrolizidine derivatives were identified with high affinity for the 5-HT4 receptor, including benzamide 12a (SC-53116), a potent and selective 5-HT4 partial agonist that exhibits efficacy in promoting antral contractions and activity in promoting gastric emptying in canine models. Also discovered were 5-HT4 receptor antagonists, including imidazopyridine amide 12h (SC-53606), which is a potent and selective 5-HT4 receptor antagonist with a pA2 value of 8.13 in the rat TMM assay. N-Methyl indole ester 13d was identified as a potent 5-HT 4 antagonist with a pA2 value of 8.93. High selectivity was observed for these pyrrolizidine derivatives versus other monoamine receptors, including 5-HT1, 5-HT2, D1, D 2, α1, α2, and β receptors. 2006 American Chemical Society.
