760152-88-3Relevant academic research and scientific papers
Design and synthesis of phosphinic acids that triply inhibit endothelin converting enzyme, angiotensin converting enzyme and neutral endopeptidase 24.11
McKittrick, Brian A.,Stamford, Andrew W.,Weng, Xiaoyu,Ma, Ke,Chackalamannil, Samuel,Czarniecki, Michael,Cleven, Renee M.,Fawzi, Ahmad B.
, p. 1629 - 1634 (2007/10/03)
We have synthesized a series of phosphinic acids as inhibitors of the metalloprotease endothelin converting enzyme (ECE). Potent ECE inhibitors 4g and 4o were identified. These compounds are members of a novel class of ECE inhibitors that are also potent inhibitors of angiotensin converting enzyme and neutral endopeptidase.
