760192-66-3Relevant academic research and scientific papers
Direct aminoalkylation of α-branched aldehydes with in situ generated glycine cation equivalents
Piper, Stefan,Risch, Nikolaus
, p. 1489 - 1496 (2004)
The efficient synthesis of β-formyl-α-aminocarboxylates 4 by direct aminoalkylation of aldehydes with in situ generated ternary iminium salts from inexpensive starting materials is described. These compounds are easily transformed into α-amino-β;,β-dialkyl-γ-butyrolactones 10 and α,α-dialkyl-β-dialkylamino-butane-1,4-diols 11 and can be used as versatile building blocks.
