760213-05-6Relevant articles and documents
A model compound of the novel organic cofactor CTQ (cysteine tryptophylquinone) of quinohemoprotein amine dehydrogenase
Murakami, Yoko,Tachi, Yoshimitsu,Itoh, Shinobu
, p. 3074 - 3079 (2007/10/03)
A model compound of the novel organic cofactor CTQ (cysteine tryptophylquinone) of quinohemoprotein amine dehydrogenase (QH-AmDH) has been synthesized for the first time by the Michael addition of phenylmethanethiol to the 3-methyl-6,7-indolequinone derivative as a key step. The model compound replicates the characteristic absorption spectrum of native CTQ as well as its redox potential in the subunit of QH-AmDH. Detailed structural and spectroscopic characterizations of the model compound have provided important insights into the substituent effects of the thioether group of CTQ. Wiley-VCH Verlag GmbH & Co, KGaA, 69451 Weinheim, Germany, 2004.