76049-83-7

Upstream product

• 60-29-7 diethyl ether 
• 33244-57-4 7-benzoyl-1H-indoline 
• 25895-60-7 sodium cyanoborohydride 
• 100-47-0 benzonitrile 
• 496-15-1 1-indoline 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Selective C-H Olefination of Indolines (C5) and Tetrahydroquinolines (C6) by Pd/S,O-Ligand Catalysis

Herein, we report a highly selective C-H olefination of directing-group-free indolines (C5) and tetrahydroquinolines (C6) by Pd/S,O-ligand catalysis. In the presence of the S,O-ligand, a wide range of challenging indolines, tetrahydroquinolines, and olefins was efficiently olefinated under mild reaction conditions. The synthetic potential of this methodology was demonstrated by the efficient olefination of several indoline-based natural products.

Intermediate and process for the preparation of 7-acylindolin-2-ones

A novel process for the preparation of 7-acylindolin-2-ones of the formula: STR1 wherein R is hydrogen, halogen, lower alkyl, lower alkoxy, or trifluoromethyl; R1 is lower alkyl, alkylphenyl, cycloalkyl, or aryl; and R2 is hydrogen, lower alkyl or benzyl is provided. The compounds are useful as intermediates in the preparation of 2-amino-3-acylphenylacetic acid compounds which possess pharmaceutical properties.