76054-82-5Relevant articles and documents
Synthesis of covalently linked parallel and antiparallel DNA duplexes containing the metal-mediated base pairs T-Hg(ii)-T and C-Ag(i)-C
Ono, Takashi,Yoshida, Kyohei,Saotome, Yuko,Sakabe, Rei,Okamoto, Itaru,Ono, Akira
supporting information; experimental part, p. 1542 - 1544 (2011/03/22)
DNA duplexes fixed in anti-parallel and parallel orientations by introducing covalent linkages have been synthesized and metal ions, Hg(ii) and Ag(i), were incorporated into pyrimidine-pyrimidine base pairs.
3'-O-FORMYL-(N-ACYL)-2'-DEOXYRIBONUCLEOSIDES AS BUILDING UNITS IN THE SYNTHESIS OF OLIGODEOXYRIBONUCLEOTIDES
Smrt, Jiri
, p. 2157 - 2169 (2007/10/02)
5'-O-Dimethoxytrityl-(N-acyl)-2'-deoxyribonucleosides afford 3'-O-formyl-(N-acyl)-2'-deoxyribonucleosides Ia-Id by the action of formic acetic anhydride followed by the action of 80percent aqueous acetic acid.The formyl group is removed from Ia-Id by treatment with 1 mol l-1 triethylamine. 3'-O-Formyl-2'-deoxythymidine (Ia) gives 3'-O-dimethoxytrityl-2'-deoxythymidine (V) by subsequent treatment with acetic anhydride, triethylamine, dimethoxytrityl chloride and methanolic ammonia.The use of compounds I for the synthesis of d-GGAGG (XIX) and d-T16 (XXXII) is described.Systems for thin-layer chromatography of 5'-O-dimethyltrityl-oligodeoxyribonucleotides on silica gel are described.
THE USE OF ZINC BROMIDE FOR REMOVAL OF DIMETHOXYTRITYL ETHERS FROM DEOXYNUCLEOSIDES
Matteucci, M. D.,Caruthers, M. H.
, p. 3243 - 3246 (2007/10/02)
Zinc bromide has been observed to detritylate specifically 5'-trityldeoxy-deoxynucleosides whereas 3'-trityl ethers are not cleaved.Of additional practical consideration and in contrast to protic acids, no depurination was observed with this reagent.