76068-42-3Relevant academic research and scientific papers
A highly regioselective Friedl?nder reaction mediated by lanthanum chloride
Chen, Ying,Huang, Jinkun,Hwang, Tsang-Lin,Li,Cui, Sheng,Chan, Johann,Bio, Matthew
body text, p. 3237 - 3241 (2012/07/31)
A highly efficient and regioselective Friedl?nder reaction of unsymmetrical 1,3-diketones with 2-aminoaryl aldehydes (ketones) is described. The methodology leads to the synthesis of a broad scope of substituted quinolines in high yield and excellent regioselectivity.
Quinoline formation via a modified Combes reaction: Examination of kinetics, substituent effects, and mechanistic pathways
Sloop, Joseph C.
experimental part, p. 110 - 117 (2010/04/05)
A comprehensive product regioselectlvity and kinetics study of the modified Combes quinoline synthesis shown below has been undertaken: This is the first reported investigation of the Combes condensation employing 19F NMR spectroscopy to monitor intermedi
