760947-84-0Relevant academic research and scientific papers
Enantioselective alkynylation of carbonyl compounds with trimethoxysilylalkynes catalyzed by lithium binaphtholate
Ueda, Tomohiro,Tanaka, Kana,Ichibakase, Tomonori,Orito, Yuya,Nakajima, Makoto
, p. 7726 - 7731 (2010)
Enantioselective alkynylation of aldehydes and ketones was accomplished using trimethoxysilylalkynes as alkynylating reagents and lithium 3,3′-diphenylbinaphtholate as a catalyst. Optically active propargylic alcohols were obtained in good to high chemica
Enantioselective alkynylation of ketones with trimethoxysilylalkynes using lithium binaphtholate as a catalyst
Tanaka, Kana,Ueda, Tomohiro,Ichibakase, Tomonori,Nakajima, Makoto
supporting information; experimental part, p. 2168 - 2169 (2010/06/13)
Chiral lithium 3,3′-diphenylbinaphtholate successfully catalyzed the alkynylation of ketone with trimethoxysilylalkyne, affording chiral tertiary propargylic alcohols in high chemical yields and high enantioselectivities. The present reaction could be extended to the alkynylation of acetylpyridine, which afforded a biologically active pyridyl propargylic alcohol in good enantioselectivity.
