760948-59-2Relevant academic research and scientific papers
Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease
Abdellatif, Khaled R.A.,Velázquez, Carlos A.,Huang, Zhangjian,Chowdhury, Morshed A.,Knaus, Edward E.
experimental part, p. 5245 - 5250 (2010/10/02)
A group of (Z)-1,1-diphenyl-2-(4-methylsulfonylphenyl)alk-1-enes were synthesized using methodologies that will allow incorporation of a [ 11C]OCH3 substituent at the para-position of the C-1 phenyl ring, a [11C]SO2/
Methylsulfonyl and hydroxyl substituents induce Z-stereocontrol in the McMurry olefination reaction
Uddin, Md. Jashim,Rao, P. N. Praveen,Knaus, Edward E.
, p. 1513 - 1516 (2007/10/03)
Aryl ketones possessing methylsulfonyl and hydroxyl substituents, that induce stereocontrol, selectively afford Z-olefins using a Zn-TiCl4 catalyzed McMurry reaction.
Design and synthesis of acyclic triaryl (Z)-olefins: A novel class of cyclooxygenase-2 (COX-2) inhibitors
Uddin, Md. Jashim,Rao, P.N. Praveen,Knaus, Edward E.
, p. 5929 - 5940 (2007/10/03)
A group of acyclic 2-alkyl-1,1-diphenyl-2-(4-methylsulfonylphenyl)ethenes was designed for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors. In vitro COX-1 and COX-2 isozyme inhibition structure-activity studies identified 1,1-diphenyl-2-(4-methylsulfonylphenyl)hex-1-ene as a highly potent (IC 50 = 0.014 μM), and an extremely selective [COX-2 selectivity index (SI) > 7142], COX-2 inhibitor that showed superior anti-inflammatory (AI) activity (ID50 = 2.5 mg/kg) relative to celecoxib (ID 50 = 10.8 mg/kg). This initial study was extended to include the design of a structurally related group of acyclic triaryl (Z)-olefins possessing an acetoxy (OAc) substituent at the para-position of the C-1 phenyl ring that is cis to a C-2 4-methylsulfonylphenyl substituent. COX-1 and COX-2 inhibition studies showed that (Z)-1-(4-acetoxyphenyl)-1-phenyl-2-(4-methylsulfonylphenyl) but-1-ene [(Z)-13b] is a potent (COX-1 IC50 = 2.4 μM; COX-2 IC50 = 0.03 μM), and selective (COX-2 SI = 81), COX-2 inhibitor which is a potent AI agent (ID50 = 4.1 mg/kg) with equipotent analgesic activity to celecoxib. A molecular modeling (docking) study showed that the SO2Me substituent of (Z)-13b inserts deep inside the 2°-pocket of the COX-2 active site, where one of the O-atoms of SO 2 group undergoes a H-bonding interaction with Phe518. The p-OAc substituent on the C-1 phenyl ring is oriented in a hydrophobic pocket comprised of Met522, Gly526, Trp387, Tyr 348, and Tyr385, and the C-2 ethyl substituent is oriented towards the mouth of the COX-2 channel in the vicinity of amino acid residues Arg120, Leu531, and Val349. Structure-activity data acquired indicate that a (Z)-olefin having cis C-1 4-acetoxyphenyl (phenyl) and C-2 4-methylsulfonylphenyl substituents, and a C-1 phenyl substituent in conjunction with either a C-2 hydrogen or short alkyl substituent provides a novel template to design acyclic olefinic COX-2 inhibitors that, like aspirin, have the potential to acetylate COX-2.
