760979-70-2

Upstream product

• 1152-61-0 N-Cbz-L-Asp 
• 760979-65-5 ((S)-3-Acetyl-2-oxo-oxazolidin-4-yl)-acetic acid benzyl ester 
• 540496-34-2 (S)-(2-oxo)oxazolidine-4-acetic acid benzyl ester 
• 4515-23-5 N-benzyloxycarbonyl-L-aspartic acid anhydride 
• 87219-29-2 benzyl (3S)-5-oxotetrahydro-3-furanylcarbamate 
• 14533-84-7 pentafluorophenyl trifloroacetate 
• 760979-69-9 {(S)-3-[2-((S)-3-Acetyl-2-oxo-oxazolidin-4-yl)-acetyl]-2-oxo-oxazolidin-4-yl}-acetic acid 

Downstream Products

• 760979-74-6 ((S)-3-{2-[(S)-3-(2-{(S)-3-[2-((S)-3-Acetyl-2-oxo-oxazolidin-4-yl)-acetyl]-2-oxo-oxazolidin-4-yl}-acetyl)-2-oxo-oxazolidin-4-yl]-acetyl}-2-oxo-oxazolidin-4-yl)-acetic acid benzyl ester 
• 760979-73-5 [(S)-3-(2-{(S)-3-[2-((S)-3-Acetyl-2-oxo-oxazolidin-4-yl)-acetyl]-2-oxo-oxazolidin-4-yl}-acetyl)-2-oxo-oxazolidin-4-yl]-acetic acid pentafluorophenyl ester 
• 760979-71-3 [(S)-3-(2-{(S)-3-[2-((S)-3-Acetyl-2-oxo-oxazolidin-4-yl)-acetyl]-2-oxo-oxazolidin-4-yl}-acetyl)-2-oxo-oxazolidin-4-yl]-acetic acid benzyl ester 

Relevant academic research and scientific papers

β-Pseudopeptide foldamers. the homo-oligomers of (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid (D-Oxac)

A total synthesis in solution and a conformational analysis of the homo-oligomers of (4R)-(2-oxo-1,3-oxazolidin-4-yl)-acetic acid (D-Oxac) to the tetramer level are described. As the D-Oxac building block contains both an oxazolidin-2-one and a β-amino acid group, it may represent a new type of conformationally constrained tool for the construction of β-pseudopeptide foldamers. A conformational investigation using NMR and an extensive, unconstrained analysis with a Monte Carlo search to the octamer level, both in water and in chloroform, showed that these homo-oligomers tend to fold in a regular helical structure in a competitive solvent, such as water. Since aqueous solutions are of major relevance for biological systems, these molecules are good candidates for application to these environments.