760979-79-1

Upstream product

• 760980-10-7 2-bromo-6-[2-(tert-butyl-dimethyl-silanyloxy)-1-hydroxymethyl-1-phenyl-ethyl]-phenol 
• 321527-38-2 7-bromo-3-(tert-butyl-dimethyl-silanyloxymethyl)-3-phenyl-3H-benzofuran-2-one 
• 74-88-4 methyl iodide 
• 760980-11-8 2-(3-bromo-2-methoxy-phenyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-propan-1-ol 

Relevant academic research and scientific papers

Studies toward diazonamide A: Initial synthetic forays directed toward the originally proposed structure

A brief introduction into the chemistry of diazonamide A (1) is followed by first-generation sequences to access the originally proposed structure for this unusual marine natural product. These explorations identified a route capable of delivering a model compound possessing the complete heteroaromatic core of the natural product, highlighting in the process several unanticipated synthetic challenges which led both to new methodology as well as an improved synthetic plan that was successfully applied to fully functionalized intermediates.

Studies toward diazonamide A: Development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure

In this article, we describe further studies toward the originally proposed structure of diazonamide A (1). After confronting a number of failures in synthesizing the heterocyclic core of that structure, success was finally realized through the developmen