76098-87-8Relevant academic research and scientific papers
Selective synthesis of (1: H-benzo [d] imidazol-2-yl)(phenyl)methanone and quinoxaline from aromatic aldehyde and o-phenylenediamine
Zhan, Zhenzhen,Ma, Haojie,Cui, Xinfeng,Jiang, Pengbo,Pu, Jinghong,Zhang, Yixin,Huang, Guosheng
supporting information, p. 5148 - 5152 (2019/06/03)
We have designed a general, inexpensive, and versatile method for the synthesis of (1H-benzo[d]imidazol-2-yl)(phenyl)methanone and the formation of C-N bonds via an aromatic aldehyde and o-phenylenediamine. In the presence of N,N-dimethylformamide/sulfur, (1H-benzo[d]imidazol-2-yl)(phenyl)methanone was obtained; however, in the absence of sulfur, quinoxaline was obtained in 1,4-dioxane. A wide range of quinoxalines and (1H-benzo[d]imidazol-2-yl)(phenyl)methanones was obtained under mild conditions.
The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors
Kim, Moon H.,Tsuhako, Amy Lew,Co, Erick W.,Aftab, Dana T.,Bentzien, Frauke,Chen, Jason,Cheng, Wei,Engst, Stefan,Goon, Levina,Klein, Rhett R.,Le, Donna T.,Mac, Morrison,Parks, Jason J.,Qian, Fawn,Rodriquez, Monica,Stout, Thomas J.,Till, Jeffrey H.,Won, Kwang-Ai,Wu, Xiang,Michael Yakes,Yu, Peiwen,Zhang, Wentao,Zhao, Yeping,Lamb, Peter,Nuss, John M.,Xu, Wei
scheme or table, p. 4979 - 4985 (2012/09/07)
Variously substituted indolin-2-ones were synthesized and evaluated for activity against KDR, Flt-1, FGFR-1 and PDGFR. Extension at the 5-position of the oxindole ring with ethyl piperidine (compound 7i) proved to be the most beneficial for attaining both biochemical and cellular potencies. Further optimization of 7i to balance biochemical and cellular potencies with favorable ADME/ PK properties led to the identification of 8h, a compound with a clean CYP profile, acceptable pharmacokinetic and toxicity profiles, and robust efficacy in multiple xenograft tumor models.
Synthesis and pharmacological properties of analogs of oxapadol, a new analgesic agent
Dostert,Langlois,Guerret,et al.
, p. 199 - 205 (2007/10/02)
A series of various heterocyclic compounds related to Oxapadol was prepared and evaluated for analgesic activity in mice. Some of them possessed significant analgesic effects; their structure activity relationships and chemistry are discussed. These compounds represent, in the authors' opinion, a unique series of analgesic agents.
