76098-94-7Relevant academic research and scientific papers
Selective synthesis of (1: H-benzo [d] imidazol-2-yl)(phenyl)methanone and quinoxaline from aromatic aldehyde and o-phenylenediamine
Zhan, Zhenzhen,Ma, Haojie,Cui, Xinfeng,Jiang, Pengbo,Pu, Jinghong,Zhang, Yixin,Huang, Guosheng
supporting information, p. 5148 - 5152 (2019/06/03)
We have designed a general, inexpensive, and versatile method for the synthesis of (1H-benzo[d]imidazol-2-yl)(phenyl)methanone and the formation of C-N bonds via an aromatic aldehyde and o-phenylenediamine. In the presence of N,N-dimethylformamide/sulfur, (1H-benzo[d]imidazol-2-yl)(phenyl)methanone was obtained; however, in the absence of sulfur, quinoxaline was obtained in 1,4-dioxane. A wide range of quinoxalines and (1H-benzo[d]imidazol-2-yl)(phenyl)methanones was obtained under mild conditions.
Synthesis and pharmacological properties of analogs of oxapadol, a new analgesic agent
Dostert,Langlois,Guerret,et al.
, p. 199 - 205 (2007/10/02)
A series of various heterocyclic compounds related to Oxapadol was prepared and evaluated for analgesic activity in mice. Some of them possessed significant analgesic effects; their structure activity relationships and chemistry are discussed. These compounds represent, in the authors' opinion, a unique series of analgesic agents.
