760992-88-9Relevant articles and documents
Discovery of 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors
Tao, Zhi-Fu,Li, Gaoquan,Tong, Yunsong,Stewart, Kent D.,Chen, Zehan,Bui, Mai-Ha,Merta, Philip,Park, Chang,Kovar, Peter,Zhang, Haiying,Sham, Hing L.,Rosenberg, Saul H.,Sowin, Thomas J.,Lin, Nan-Horng
, p. 5944 - 5951 (2008/09/16)
An extensive structure-activity relationship study of the 3-position of a series of tricyclic pyrazole-based Chk1 inhibitors is described. As a result, 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles (4) and 4′-(1,4-dihydro-indeno[1,2-c]pyrazol-3
