761001-56-3

Upstream product

• 124-46-9 guanidine hydrogen carbonate 
• 65843-60-9 methyl 3-acetyl-4-(benzyloxy)benzoate 
• 593-85-1 guanidine carbonate 
• 16357-40-7 3-acetyl-4-hydroxybenzoic acid 
• 57009-12-8 methyl 3-acetyl-4-hydroxybenzoate 

Downstream Products

• 761001-57-4 3-(2-aminopyrimidin-4-yl)-4-(benzyloxy)-N-methoxy-N-methylbenzamide 

Relevant academic research and scientific papers

Synthesis of (3-(2-aminopyrimidin-4-yl)-4-hydroxyphenyl)phenyl methanone analogues as inhibitors of vascular endothelial growth factor receptor-2 kinase

Angiogenesis is critical for tumor growth and mediated mainly by vascular endothelial growth factor (VEGF) signaling. Inhibition of the VEGF signaling pathway has emerged as one of the promising approaches for cancer therapy. VEGF receptor 2 (VEGFR-2) is

NOVEL 3-(2-AMINO-4-PYRIMIDINYL)-4-HYDROXYPHENYL KETONE DERIVATIVES

The present invention relates to novel compounds having 3-(2-amino-4-pyrimidinyl)-4-hydroxyphenyl ketone structure, as being illustrated in Formula 1, for inhibition of angiogenesis receptor tyrosine kinases, in particular, VEGF receptor 2 kinase ("KDR")