76103-96-3

Upstream product

• 263239-24-3 1,1-dimethylethyl 2-chloro-β-oxobenzenepropionate 
• 78181-04-1 5-(2-chlorobenzoyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 609-65-4 o-chlorobenzoyl chloride 
• 205985-98-4 methyl 2-chlorobenzoylacetate 
• 2142-68-9 1-(2-chlorophenyl)ethanone 

Downstream Products

• 76103-64-5 1-(2-Chloro-phenyl)-2-(1-methyl-pyrrolidin-2-yl)-ethanone 
• 943914-55-4 2-chloro-N-cyclobutyl-β-oxobenzenepropanamide 
• 1414943-21-7 (S)-1-(2-chlorophenyl)-4-nitro-3-phenylbutan-1-one 
• 1644085-86-8 1-(2-chlorophenyl)-4,4,4-trifluoro-3-hydroxybutan-1-one 
• 1459141-00-4 C₂₃H₁₈ClNO₃ 
• 1379537-24-2 C₁₇H₂₄ClNO₄S 

Relevant academic research and scientific papers

Enantioselective decarboxylative Mannich reaction of β-keto acids withC-alkynylN-BocN,O-acetals: access to chiral β-keto propargylamines

The chiral keto-substituted propargylamines are an essential class of multifunctional compounds in the field of organic and pharmaceutical synthesis and have attracted considerable attention, but the related synthetic approaches remain limited. Therefore, a concise and efficient method for the enantioselective synthesis of β-keto propargylaminesviachiral phosphoric acid-catalyzed asymmetric Mannich reaction between β-keto acids andC-alkynylN-BocN,O-acetals as easily availableC-alkynyl imine precursors has been demonstrated here, affording a broad scope of β-ketoN-Boc-propargylamines in high yields (up to 97%) with generally high enantioselectivities (up to 97?:?3 er).

Enaminone amides as novel orally active GABAA receptor modulators

A series of enaminone esters and amides have been developed as potent allosteric modulators of γ-aminobutyric acidA (GABA A) receptors. The compounds bind to a novel modulatory site that is independent of the benzodiazepine (BZ), isosteric GABA, and neuroactive steroid binding sites. Structure-activity relationship (SAR) studies resulted in the synthesis of the c-Bu amide 16h with an in vitro potency of 7 nM based on inhibition of [35S]TBPS binding. The activity of the enaminones as positive allosteric modulators was confirmed with electrophysiological measurements in oocytes expressing α1β2γ 2L GABAA receptors. The i-Pr, s-Bu, c-Pr, and c-Bu amides (16e-h) were orally active in mice with profound central nervous system depressant effects. The i-Pr amide 16e was an orally active anxiolytic in the mouse light-dark paradigm.

2-Substituted-4-aryl-5-thiazolecarboxylic acids and their derivatives as safening agents

These compounds have been found to be effective in reducing herbicidal injury to direct-seeded rice caused by 2-chloro-2',6'-diethyl-N-(butoxymethyl)acetanilide.