76108-75-3Relevant academic research and scientific papers
Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines
Wang, Chao,Rui, Xiyan,Si, Dongjuan,Dai, Rupeng,Zhu, Yueyue,Wen, Hongmei,Li, Wei,Liu, Jian
supporting information, p. 2825 - 2833 (2021/04/26)
The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazole and quinazoline derivatives from readily available benzaldehyde, benzylamine and hydroxylamine or aniline has been developed. Both the cascade reaction sequences involves nucleophilic addition of C?N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation. This synthesis methodology demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provides strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials. (Figure presented.).
The Nitrile Oxide-Isocyanate Rearrangement
Taylor, Giles A.
, p. 1181 - 1184 (2007/10/02)
The thermal rearrangement of 2,4,6-trimethylbenzonitrile N-oxide to the corresponding isocyanate has been investigated by double isotopic labelling and kinetic experiments.Rearrangement proceeds with exchange of oxygen atoms, and this exchange occurs exclusively between nitrile oxide molecules.Kinetic results suggest that the pathway involves a polymerisation, catalysed either by electrophiles or by nucleophiles, followed by decomposition of the polymer.The rearrangement is catalysed at room temperature by trifluoracetic acid.A synthesis of (18)O-labelled hydroxylamine is reported.
