7612-88-6

Usage

Uses

Used in Pharmaceutical Industry:
4-(bromomethyl)benzenesulfonyl fluoride is used as a building block for the synthesis of various pharmaceutical products. It is utilized in the development of new and innovative chemical processes to create a wide range of chemical compounds.
Used in Agrochemical Industry:
4-(bromomethyl)benzenesulfonyl fluoride is used as a building block for the synthesis of various agrochemical products. It plays a crucial role in the development of new and innovative chemical processes to create a wide range of chemical compounds for agricultural applications.

Upstream product

• 455-16-3 p-toluenesulfonyl fluoride 
• 98-59-9 p-toluenesulfonyl chloride 
• 66176-39-4 4-(bromomethyl)benzene-1-sulfonyl chloride 

Downstream Products

• 1613052-75-7 1-(4-(fluorosulfonyl)benzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Antitumor compound, synthesis method and applications thereof

The invention belongs to the field of medicinal chemistry, and particularly relates to an antitumor compound, a synthesis method and applications thereof, wherein the compound has a structure represented by a general formula I or a general formula II, and

An in situ combinatorial methodology to synthesize and screen chemical probes

Chemical probes that label proteins of interest in the context of complex biological samples are useful research tools. The reactive group that forms the covalent bond with the target protein has a large effect on the selectivity and selecting the appropriate group determines the success of a probe. We here report the development of a combinatorial methodology based on imine chemistry that enables straightforward in situ synthesis and screening of different reactive groups and thereby simplifies identification of probe leads. Using our methodology, we found chemical probes targeting BirA and chloramphenicol acetyl transferase, two proteins associated with antibacterial activity and resistance.

Sulfur(VI) fluoride compounds and methods for the preparation thereof

This application describes a compound represented by Formula (I): (I) wherein: Y is a biologically active organic core group comprising one or more of an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group, to which Z is covalently bonded; n is 1, 2, 3, 4 or 5; m is 1 or 2; Z is O, NR, or N; X1 is a covalent bond or —CH2CH2—, X2 is O or NR; and R comprises H or a substituted or unsubstituted group selected from an aryl group, a heteroaryl aryl group, a nonaromatic hydrocarbyl group, and a nonaromatic heterocyclic group. Methods of preparing the compounds, methods of using the compounds, and pharmaceutical compositions comprising the compounds are described as well.

Synthesis and pharmacological evaluation of analogues of benzyl quinolone carboxylic acid (BQCA) designed to bind irreversibly to an allosteric site of the M1 muscarinic acetylcholine receptor

Activation of the M1 muscarinic acetylcholine receptor (mAChR) is a prospective treatment for alleviating cognitive decline experienced in central nervous system (CNS) disorders. Current therapeutics indiscriminately enhance the activity of the endogenous neurotransmitter ACh, leading to side effects. BQCA is a positive allosteric modulator and allosteric agonist at the M1 mAChR that has high subtype selectivity and is a promising template from which to generate higher affinity, more pharmacokinetically viable drug candidates. However, to efficiently guide rational drug design, the binding site of BQCA needs to be conclusively elucidated. We report the synthesis and pharmacological validation of BQCA analogues designed to bind irreversibly to the M1 mAChR. One analogue in particular, 11, can serve as a useful structural probe to confirm the location of the BQCA binding site; ideally, by co-crystallization with the M1 mAChR. Furthermore, this ligand may also be used as a pharmacological tool with a range of applications.