76129-15-2Relevant academic research and scientific papers
The first dipolar spirocycle based on 10-(benzylamino)colchicine
Tkachuk, Anna V.,Kurbatov, Sergey V.,Morozov, Pavel G.,Borodkin, Gennadiy S.
, p. 948 - 950 (2015)
We have synthesized the first dipolar spirocyclic σ-complex of Meisenheimer type from 10-(benzylamino)colchicine and trinitrobenzene. The chirality of colchicine moiety resulted in magnetic non-equivalence of protons in the trinitrophenyl ring, enabling t
Quantitative Structure-Activity Relationships of Colchicines against P388 Leukemia in Mice
Quinn, Frank R.,Beisler, John A.
, p. 251 - 256 (2007/10/02)
A quantitative structure-activity relationship (QSAR) was derived for colchicine and 14 analogues acting against P388 lymphocytic leukemia in mice.Twelve additional compounds were synthesized to reinforce and confirm the correlation.The final correlation
