76131-81-2

Upstream product

• 78687-70-4 2-Allyl-2-(2-oxo-4-vinyl-azetidin-1-yl)-malonic acid bis-(4-nitro-benzyl) ester 
• 78687-67-9 2-Hydroxy-2-(2-oxo-4-vinyl-azetidin-1-yl)-malonic acid bis-(4-nitro-benzyl) ester 
• 78687-68-0 2-Chloro-2-(2-oxo-4-vinyl-azetidin-1-yl)-malonic acid bis-(4-nitro-benzyl) ester 
• 78687-69-1 2-(2-Oxo-4-vinyl-azetidin-1-yl)-malonic acid bis-(4-nitro-benzyl) ester 
• 65750-58-5 bis(p-nitrobenzyl) ketomalonate 
• 78687-71-5 2-(2-Formyl-4-oxo-azetidin-1-yl)-2-(2-oxo-ethyl)-malonic acid bis-(4-nitro-benzyl) ester 

Downstream Products

• 78687-74-8 p-nitrobenzyl-2-benzoyloxymethyl-Δ¹-penem-3-carboxylate 
• 78687-73-7 3-Benzoyloxymethyl-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 
• 78687-72-6 3-Hydroxymethyl-7-oxo-1-aza-bicyclo[3.2.0]hept-3-ene-2,2-dicarboxylic acid bis-(4-nitro-benzyl) ester 

Relevant academic research and scientific papers

SYNTHESIS OF Δ1-CARBAPENEM DERIVATE BY ALDOL CONDENSATION METHOD

The Δ1-carbapenem derivate(6) was prepared by the aldol condensation of the dialdehydic compound(5) with piperidinium acetate.Careful hydride reduction followed by benzoylation gave 7b, which was succesfully decarboxylated to 8.The X-ray struct