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Upstream product

• 1258421-41-8 C₁₉H₂₂N₂O₃ 

Downstream Products

• 889864-34-0 C₃₄H₃₁F₃N₄O₄ 
• 889864-43-1 C₃₁H₃₂F₃N₃O₃ 
• 889863-99-4 C₃₃H₃₀F₃N₃O₄ 
• 720682-77-9 C₃₁H₂₇F₃N₄O₃ 
• 889864-08-8 C₃₃H₃₀F₃N₃O₄ 
• 889864-18-0 C₃₃H₃₀F₃N₃O₃ 
• 1258421-37-2 C₂₆H₂₆N₂O 
• 1258421-34-9 C₃₈H₄₂N₄O₂ 
• 1116686-79-3 (S)-2-phenyl-N₁-propylethane-1,2-diamine 

Relevant academic research and scientific papers

Synthesis and evaluation of pseudopeptidic fluorescence pH probes for acidic cellular organelles: In vivo monitoring of bacterial phagocytosis by multiparametric flow cytometry

A new family of fluorescent anthracenic pH probes has been synthesized, chemically characterized, and their photophysical properties have been investigated by steady-state and time-resolved fluorescence spectroscopy. The ability of these compounds to monitor pH has been investigated in solution and it was found that molecules 1-12 can act as fluorescent sensors for pH in a range between 4.6 and 6.5. This range corresponds to the pH of acidic organelles in the cell (pH 4.5-6.0) for which a limited number of probes are described. The acid-base behavior of each sensor varies slightly depending on the nature of substituents close to the amines present in the molecules. Thus, the pK a of this family of compounds can be finely tuned by the appropriate selection of the synthetic building blocks at the design stage. To test the potential diagnostic applications of this family of probes, macrocyclic pseudopeptide 2 was used to monitor the phagocytosis of a culture of GFP-labelled bacteria by human monocytic cells U937 using flow cytometry as the analytical tool. It was found that the occurrence of bacterial killing was concomitant with the production of reactive oxygen species and a drop in pH, the latter monitored indirectly by macrocyclic sensor 2, which suggests its potential use for diagnostic purposes. A new family of anthracenic macrocycles has been synthesized that can act as fluorescent probes for pH in the range 4.6-6.5. The pKa values of these compounds can be finely tuned. In flow cytometry experiments, it was found that bacterial killing by human monocytes (U937) occurred with a simultaneous drop in pH, which was monitored by one of the macrocyclic sensors.

Discovery of potent and orally active MTP inhibitors as potential anti-obesity agents

We have successfully identified a number of novel MTP inhibitors with single digit nanomolar potency. Analogues 10aq and 10dq demonstrated in vivo efficacy in a murine gut retention assay.