761424-47-9Relevant academic research and scientific papers
Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: Discovery of YM543
Ikegai, Kazuhiro,Imamura, Masakazu,Suzuki, Takayuki,Nakanishi, Keita,Murakami, Takeshi,Kurosaki, Eiji,Noda, Atsushi,Kobayashi, Yoshinori,Yokota, Masayuki,Koide, Tomokazu,Kosakai, Kazuhiro,Ohkura, Yasufumi,Takeuchi, Makoto,Tomiyama, Hiroshi,Ohta, Mitsuaki
, p. 3934 - 3948 (2013/07/19)
Here, a series of C-glucosides with azulene rings in the aglycon moiety was synthesized and the inhibitory activities toward hSGLT1 and hSGLT2 were evaluated. Starting from the azulene derivative 7 which had relatively good SGLT2 inhibitory activity, comp
