761424-64-0Relevant academic research and scientific papers
Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus (1)
Nomura, Sumihiro,Sakamaki, Shigeki,Hongu, Mitsuya,Kawanishi, Eiji,Koga, Yuichi,Sakamoto, Toshiaki,Yamamoto, Yasuo,Ueta, Kiichiro,Kimata, Hirotaka,Nakayama, Keiko,Tsuda-Tsukimoto, Minoru
scheme or table, p. 6355 - 6360 (2010/11/03)
We discovered that C-glucosides 4 bearing a heteroaromatic ring formed metabolically more stable inhibitors for sodium-dependent glucose cotransporter 2 (SGLT2) than the O-glucoside, 2 (T-1095). A novel thiophene derivative 4b-3 (canagliflozin) was a highly potent and selective SGLT2 inhibitor and showed pronounced anti-hyperglycemic effects in high-fat diet fed KK (HF-KK) mice.
